Matches in SemOpenAlex for { <https://semopenalex.org/work/W3176261053> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W3176261053 endingPage "LB" @default.
- W3176261053 startingPage "216" @default.
- W3176261053 abstract "Glucagon regulates hepatic glucose production and hyperglucagonemia contributes to diabetes. Equally important, glucagon may regulate amino acid (AA) levels that in turn control glucagon secretion. Hepatic steatosis may uncouple glucagon’s effect on AA metabolism causing impaired actions of glucagon (resistance) on AA metabolism but not glucose production, thereby creating a diabetogenic circle. In order to quantify glucagon’s effect on AA metabolism, we developed and evaluated a glucagon sensitivity test. The test consists of a bolus-infusion of glucagon (200 μg) and an AA infusion (330 mg/min/kg body weight for 45 min) on two separate days following an overnight fast. Liver fat was measured using magnetic resonance imaging. Preliminary data from six individuals without diabetes (HbA1c < 48mmol/mol) including three lean controls (CON) (mean ± SD; Age: 32 ± 7 years, liver fat: 4.1 ± 1 %, BMI; 22 ± 2 kg/m2) and three individuals with obesity (OBE) (47 ± 12 years, 12 ± 6 %, 30 ± 4 kg/m2) are presented. A glucagon injection reduced AA levels 29% less in OBE compared to CON (dAUC0-120min; 41 ± 6 vs. 29 ± 10 mmol/L x min) during the fasted state. AA levels increased 33% more in OBE compared to CON during an AA infusion (iAUC0-45min; 118 ± 28 vs. 89 ± 12 mmol/L x min). We conclude that glucagon sensitivity towards AA metabolism may be evaluated by a bolus-infusion of glucagon and an AA infusion, and that hepatic steatosis may cause glucagon resistance.View largeDownload slideView largeDownload slide DisclosureS. Kjeldsen: None. E. B. Rashu: None. L. Gluud: None. S. B. Haugaard: None. J. J. Holst: Consultant; Self; Novo Nordisk, Other Relationship; Self; Antag Therapeutics, Bainan Biotech, MSD Corporation, Novo Nordisk, Other Relationship; Spouse/Partner; Antag Therapeutics, Bainan Biotech, Synklino ApS. J. Rungby: None. N. J. Wewer albrechtsen: Research Support; Self; Mercodia, Novo Nordisk A/S, Regeneron Pharmaceuticals Inc., Speaker’s Bureau; Self; Merck & Co., Inc., Mercodia. N. J. Jensen: None. M. Nilsson: None. J. D. Nybing: None. F. H. Linden: None. E. Høgh-schmidt: None. M. P. Boesen: None. S. Madsbad: Advisory Panel; Self; AstraZeneca; Boehringer Ingelheim; Eli Lilly; Merck Sharp & Dohme; Novo Nordisk; Sanofi, Research Support; Self; Novo Nordisk, Boehringer Ingelheim, Speaker’s Bureau; Self; AstraZeneca; Boehringer Ingelheim; Merck Sharp & Dohme; Novo Nordisk; Sanofi. H. Vilstrup: None.FundingNovo Nordisk Foundation (116113)" @default.
- W3176261053 created "2021-07-05" @default.
- W3176261053 creator A5006706174 @default.
- W3176261053 creator A5009212606 @default.
- W3176261053 creator A5030437138 @default.
- W3176261053 creator A5038969379 @default.
- W3176261053 creator A5039506264 @default.
- W3176261053 creator A5040386957 @default.
- W3176261053 creator A5045229961 @default.
- W3176261053 creator A5045316899 @default.
- W3176261053 creator A5047497742 @default.
- W3176261053 creator A5056562539 @default.
- W3176261053 creator A5061040174 @default.
- W3176261053 creator A5065850266 @default.
- W3176261053 creator A5072113566 @default.
- W3176261053 creator A5075627655 @default.
- W3176261053 creator A5083668499 @default.
- W3176261053 date "2021-06-01" @default.
- W3176261053 modified "2023-10-14" @default.
- W3176261053 title "216-LB: Development and Evaluation of a Glucagon Sensitivity Test in Humans" @default.
- W3176261053 doi "https://doi.org/10.2337/db21-216-lb" @default.
- W3176261053 hasPublicationYear "2021" @default.
- W3176261053 type Work @default.
- W3176261053 sameAs 3176261053 @default.
- W3176261053 citedByCount "0" @default.
- W3176261053 crossrefType "journal-article" @default.
- W3176261053 hasAuthorship W3176261053A5006706174 @default.
- W3176261053 hasAuthorship W3176261053A5009212606 @default.
- W3176261053 hasAuthorship W3176261053A5030437138 @default.
- W3176261053 hasAuthorship W3176261053A5038969379 @default.
- W3176261053 hasAuthorship W3176261053A5039506264 @default.
- W3176261053 hasAuthorship W3176261053A5040386957 @default.
- W3176261053 hasAuthorship W3176261053A5045229961 @default.
- W3176261053 hasAuthorship W3176261053A5045316899 @default.
- W3176261053 hasAuthorship W3176261053A5047497742 @default.
- W3176261053 hasAuthorship W3176261053A5056562539 @default.
- W3176261053 hasAuthorship W3176261053A5061040174 @default.
- W3176261053 hasAuthorship W3176261053A5065850266 @default.
- W3176261053 hasAuthorship W3176261053A5072113566 @default.
- W3176261053 hasAuthorship W3176261053A5075627655 @default.
- W3176261053 hasAuthorship W3176261053A5083668499 @default.
- W3176261053 hasConcept C126322002 @default.
- W3176261053 hasConcept C134018914 @default.
- W3176261053 hasConcept C17093226 @default.
- W3176261053 hasConcept C185592680 @default.
- W3176261053 hasConcept C2778563252 @default.
- W3176261053 hasConcept C2779306644 @default.
- W3176261053 hasConcept C2908748658 @default.
- W3176261053 hasConcept C43376680 @default.
- W3176261053 hasConcept C555293320 @default.
- W3176261053 hasConcept C62231903 @default.
- W3176261053 hasConcept C71924100 @default.
- W3176261053 hasConceptScore W3176261053C126322002 @default.
- W3176261053 hasConceptScore W3176261053C134018914 @default.
- W3176261053 hasConceptScore W3176261053C17093226 @default.
- W3176261053 hasConceptScore W3176261053C185592680 @default.
- W3176261053 hasConceptScore W3176261053C2778563252 @default.
- W3176261053 hasConceptScore W3176261053C2779306644 @default.
- W3176261053 hasConceptScore W3176261053C2908748658 @default.
- W3176261053 hasConceptScore W3176261053C43376680 @default.
- W3176261053 hasConceptScore W3176261053C555293320 @default.
- W3176261053 hasConceptScore W3176261053C62231903 @default.
- W3176261053 hasConceptScore W3176261053C71924100 @default.
- W3176261053 hasIssue "Supplement 1" @default.
- W3176261053 hasLocation W31762610531 @default.
- W3176261053 hasOpenAccess W3176261053 @default.
- W3176261053 hasPrimaryLocation W31762610531 @default.
- W3176261053 hasRelatedWork W1855195526 @default.
- W3176261053 hasRelatedWork W1971462614 @default.
- W3176261053 hasRelatedWork W1972585133 @default.
- W3176261053 hasRelatedWork W2005928606 @default.
- W3176261053 hasRelatedWork W2052631352 @default.
- W3176261053 hasRelatedWork W2068655959 @default.
- W3176261053 hasRelatedWork W2091233188 @default.
- W3176261053 hasRelatedWork W2400917451 @default.
- W3176261053 hasRelatedWork W2402059647 @default.
- W3176261053 hasRelatedWork W4319166348 @default.
- W3176261053 hasVolume "70" @default.
- W3176261053 isParatext "false" @default.
- W3176261053 isRetracted "false" @default.
- W3176261053 magId "3176261053" @default.
- W3176261053 workType "article" @default.