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- W3176273609 abstract "The availability and uptake of nutrients play a critical role in the generation of adequate immune responses. In particular, the metabolic demands of T lymphocytes increase following activation to provide energy for proliferation and other important effector functions. Glucose, one of the major energy sources of T cells, can be transported into cells via several glucose transporters, including GLUT-1. However, the distribution of GLUT-1 on T cell subsets remains unclear. Therefore, the goal of the current study was to evaluate the effect of T cell activation on GLUT-1 expression in CD4+ and CD8+ T cells. Peripheral blood was collected from healthy subjects (20–40 years old), PBMCs were isolated using Ficoll-Hypaque Plus, and T cells were stimulated using 1 μg/ml of anti-CD3/CD28 antibodies. Following 3-day cultures, T cells were harvested, counted and GLUT-1 expression was quantified on both unactivated and activated CD4+ and CD8+ T cells by flow cytometry. GLUT-1 expression increased significantly, on CD4+and CD8+ T cells (20-fold and 10-fold, respectively; P<0.05) following activation. Our results demonstrate that CD4+ and CD8+ T cells up-regulate the surface expression of GLUT-1 upon activation. These results suggest that increased glucose uptake via the GLUT-1 transporter is a common feature of all activated T cells and may be a target for therapy to enhance T cell function. Grant Funding Source: Penn State internal funding" @default.
- W3176273609 created "2021-07-05" @default.
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- W3176273609 date "2012-04-01" @default.
- W3176273609 modified "2023-09-27" @default.
- W3176273609 title "GLUT‐1 transporter expression is up‐regulated on human CD4+ and CD8+ T lymphocytes following T cell activation" @default.
- W3176273609 doi "https://doi.org/10.1096/fasebj.26.1_supplement.1027.15" @default.
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