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- W3176286743 abstract "Abstract Epigenetic changes are required for normal development, yet the nature and respective contribution of factors that drive epigenetic variation in humans remain to be fully characterized. Here, we assessed how the blood DNA methylome of 884 adults is affected by DNA sequence variation, age, sex and 139 factors relating to life habits and immunity. Furthermore, we investigated whether these effects are mediated or not by changes in cellular composition, measured by deep immunophenotyping. We show that DNA methylation differs substantially between naïve and memory T cells, supporting the need for adjustment on these cell-types. By doing so, we find that latent cytomegalovirus infection drives DNA methylation variation and provide further support that the increased dispersion of DNA methylation with aging is due to epigenetic drift. Finally, our results indicate that cellular composition and DNA sequence variation are the strongest predictors of DNA methylation, highlighting critical factors for medical epigenomics studies." @default.
- W3176286743 created "2021-07-05" @default.
- W3176286743 creator A5012236358 @default.
- W3176286743 creator A5018234533 @default.
- W3176286743 creator A5021605951 @default.
- W3176286743 creator A5023295967 @default.
- W3176286743 creator A5052489041 @default.
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- W3176286743 creator A5081044798 @default.
- W3176286743 creator A5082761941 @default.
- W3176286743 creator A5083176551 @default.
- W3176286743 creator A5091772545 @default.
- W3176286743 date "2021-06-24" @default.
- W3176286743 modified "2023-10-17" @default.
- W3176286743 title "The Immune Factors Driving DNA Methylation Variation in Human Blood" @default.
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