FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3176291228> ?p ?o ?g. }

• W3176291228 endingPage "217" @default.
• W3176291228 startingPage "203" @default.
• W3176291228 abstract "It is noteworthy that colon cancer is the fourth place in new cases and the fifth in mortalities according to global cancer statistics 2018. Tumorigenesis displays specific correlation with metabolic alterations. A variety of metabolites, including ornithine (Orn), are related to colon cancer according to sources of disease metabolic information retrieval in human metabolome database. The metabolic regulation of Orn pathway is a key link in the survival of cancer cells. In this study, the plasma Orn levels in colon cancer patients and healthy participants were measured by liquid chromatography tandem mass spectrometry, and the metabolic disturbances of Orn in colon cancer were identified. Based on exploring the pathway structure of Orn metabolism via MetaboAnalyst and Kyoto Encyclopedia of Genes and Genomes database, we found that the upstream and downstream metabolites included arginine (Arg) and N1, N12-diacetylspermine (DiAcSpm). We observed that the Arg-Orn-DiAcSpm metabolic pathway was up-regulated in colon cancer through pathway analysis. We used multivariate data modelling to build a regression diagnosis model based on the three metabolites for colon cancer, and the diagnosis capability of this model was analyzed via receiver operating characteristic curve. This study provides a theoretical basis for further feature description of tumor metabolic pathway, which may lead to discover new therapeutic targets and drugs against colon cancer. Multivariate data modelling is expected to be a novel technology for developing noninvasive screening tool of cancer." @default.
• W3176291228 created "2021-07-05" @default.
• W3176291228 creator A5015282914 @default.
• W3176291228 creator A5036473002 @default.
• W3176291228 creator A5042301216 @default.
• W3176291228 creator A5044481155 @default.
• W3176291228 creator A5049584494 @default.
• W3176291228 creator A5055027717 @default.
• W3176291228 date "2021-01-01" @default.
• W3176291228 modified "2023-09-25" @default.
• W3176291228 title "Alteration of Ornithine Metabolic Pathway in Colon Cancer and Multivariate Data Modelling for Cancer Diagnosis" @default.
• W3176291228 cites W1799482054 @default.
• W3176291228 cites W1964889413 @default.
• W3176291228 cites W1969979976 @default.
• W3176291228 cites W1986057581 @default.
• W3176291228 cites W2057495870 @default.
• W3176291228 cites W2080148196 @default.
• W3176291228 cites W2119097025 @default.
• W3176291228 cites W2121463566 @default.
• W3176291228 cites W2122899404 @default.
• W3176291228 cites W2127049578 @default.
• W3176291228 cites W2128183409 @default.
• W3176291228 cites W2155680682 @default.
• W3176291228 cites W2158595135 @default.
• W3176291228 cites W2162790428 @default.
• W3176291228 cites W2166246882 @default.
• W3176291228 cites W2182366902 @default.
• W3176291228 cites W2270334412 @default.
• W3176291228 cites W2290653689 @default.
• W3176291228 cites W2523536421 @default.
• W3176291228 cites W2563805999 @default.
• W3176291228 cites W2889646458 @default.
• W3176291228 cites W2902209163 @default.
• W3176291228 cites W2919162104 @default.
• W3176291228 cites W2965914508 @default.
• W3176291228 cites W2989789471 @default.
• W3176291228 cites W2999464682 @default.
• W3176291228 cites W3034548008 @default.
• W3176291228 cites W4248363110 @default.
• W3176291228 doi "https://doi.org/10.32604/oncologie.2021.016155" @default.
• W3176291228 hasPublicationYear "2021" @default.
• W3176291228 type Work @default.
• W3176291228 sameAs 3176291228 @default.
• W3176291228 citedByCount "1" @default.
• W3176291228 countsByYear W31762912282022 @default.
• W3176291228 crossrefType "journal-article" @default.
• W3176291228 hasAuthorship W3176291228A5015282914 @default.
• W3176291228 hasAuthorship W3176291228A5036473002 @default.
• W3176291228 hasAuthorship W3176291228A5042301216 @default.
• W3176291228 hasAuthorship W3176291228A5044481155 @default.
• W3176291228 hasAuthorship W3176291228A5049584494 @default.
• W3176291228 hasAuthorship W3176291228A5055027717 @default.
• W3176291228 hasBestOaLocation W31762912281 @default.
• W3176291228 hasConcept C104317684 @default.
• W3176291228 hasConcept C121608353 @default.
• W3176291228 hasConcept C126322002 @default.
• W3176291228 hasConcept C135870905 @default.
• W3176291228 hasConcept C143998085 @default.
• W3176291228 hasConcept C150194340 @default.
• W3176291228 hasConcept C152724338 @default.
• W3176291228 hasConcept C162317418 @default.
• W3176291228 hasConcept C192989942 @default.
• W3176291228 hasConcept C21565614 @default.
• W3176291228 hasConcept C2776796294 @default.
• W3176291228 hasConcept C2777468819 @default.
• W3176291228 hasConcept C38180746 @default.
• W3176291228 hasConcept C502942594 @default.
• W3176291228 hasConcept C515207424 @default.
• W3176291228 hasConcept C526805850 @default.
• W3176291228 hasConcept C55493867 @default.
• W3176291228 hasConcept C555283112 @default.
• W3176291228 hasConcept C60644358 @default.
• W3176291228 hasConcept C62231903 @default.
• W3176291228 hasConcept C71924100 @default.
• W3176291228 hasConcept C86803240 @default.
• W3176291228 hasConceptScore W3176291228C104317684 @default.
• W3176291228 hasConceptScore W3176291228C121608353 @default.
• W3176291228 hasConceptScore W3176291228C126322002 @default.
• W3176291228 hasConceptScore W3176291228C135870905 @default.
• W3176291228 hasConceptScore W3176291228C143998085 @default.
• W3176291228 hasConceptScore W3176291228C150194340 @default.
• W3176291228 hasConceptScore W3176291228C152724338 @default.
• W3176291228 hasConceptScore W3176291228C162317418 @default.
• W3176291228 hasConceptScore W3176291228C192989942 @default.
• W3176291228 hasConceptScore W3176291228C21565614 @default.
• W3176291228 hasConceptScore W3176291228C2776796294 @default.
• W3176291228 hasConceptScore W3176291228C2777468819 @default.
• W3176291228 hasConceptScore W3176291228C38180746 @default.
• W3176291228 hasConceptScore W3176291228C502942594 @default.
• W3176291228 hasConceptScore W3176291228C515207424 @default.
• W3176291228 hasConceptScore W3176291228C526805850 @default.
• W3176291228 hasConceptScore W3176291228C55493867 @default.
• W3176291228 hasConceptScore W3176291228C555283112 @default.
• W3176291228 hasConceptScore W3176291228C60644358 @default.
• W3176291228 hasConceptScore W3176291228C62231903 @default.
• W3176291228 hasConceptScore W3176291228C71924100 @default.
• W3176291228 hasConceptScore W3176291228C86803240 @default.
• W3176291228 hasIssue "2" @default.

• next