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- W3176299090 abstract "Mycobacteria, which cause tuberculosis and related diseases, possess a diverse set of complex envelope lipids that provide remarkable tolerance to antibiotics and are major virulence factors that drive pathogenesis. Recently, metabolic labeling and bio-orthogonal chemistry have been harnessed to develop chemical probes for tagging specific lipids in live mycobacteria, enabling a range of new basic and translational research avenues. A toolbox of probes has been developed for labeling mycolic acids and their derivatives, including trehalose-, arabinogalactan-, and protein-linked mycolates, as well as newer probes for labeling phthiocerol dimycocerosates (PDIMs) and potentially other envelope lipids. These lipid-centric tools have yielded fresh insights into mycobacterial growth and host interactions, provided new avenues for drug target discovery and characterization, and inspired innovative diagnostic and therapeutic strategies." @default.
- W3176299090 created "2021-07-05" @default.
- W3176299090 creator A5071273878 @default.
- W3176299090 creator A5085088306 @default.
- W3176299090 date "2021-12-01" @default.
- W3176299090 modified "2023-09-30" @default.
- W3176299090 title "Chemical probes for tagging mycobacterial lipids" @default.
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- W3176299090 doi "https://doi.org/10.1016/j.cbpa.2021.05.009" @default.
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