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- W3176356918 abstract "Building on clinical case reports of the abscopal effect, there has been considerable interest in the synergistic effects of radiation and immunotherapies for the treatment of cancer. Here, the first radiolabeled antibody-recruiting small molecule that can chelate a variety of cytotoxic radionuclides is described. The platform consists of a tunable antibody-binding domain against a serum antibody of interest (e.g., dinitrophenyl hapten) to recruit endogenous antibodies that activate effector cell function, a chelate capable of binding diagnostic and therapeutic radiometals, and a tetrazine for bioorthogonal coupling with trans-cyclooctene-modified targeting vectors. The dinitrophenyl-tetrazine ligand was shown to both affect dose-dependent antibody recruitment and immune cell function (phagocytosis) in vitro, and the bisphosphonate 177Lu-complex was shown to accumulate at sites of calcium accretion in vivo, which was achieved using both active and pretargeting strategies." @default.
- W3176356918 created "2021-07-05" @default.
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- W3176356918 date "2021-06-23" @default.
- W3176356918 modified "2023-09-25" @default.
- W3176356918 title "A Versatile Platform for the Development of Radiolabeled Antibody-Recruiting Small Molecules" @default.
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- W3176356918 doi "https://doi.org/10.1021/acs.molpharmaceut.1c00187" @default.
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