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• W3176367787 abstract "A detailed understanding of the mismatched base-pairing interactions in DNA will help reveal genetic diseases and provide a theoretical basis for the development of targeted drugs. Here, we utilized mononucleotide fragment to simulate mismatch DNA interactions in a local hydrophobic microenvironment. The bipyridyl-type bridging ligands were employed as a mild stabilizer to stabilize the GG mismatch containing complexes, allowing mismatch to be visualized based on X-ray crystallography. Five single crystals of 2′-deoxyguanosine–5′–monophosphate (dGMP) metal complexes were designed and obtained via the process of self-assembly. Crystallographic studies clearly reveal the details of the supramolecular interaction between mononucleotides and guest intercalators. A novel guanine–guanine base mismatch pattern with unusual ( high anti )–( high anti ) type of arrangement around the glycosidic angle conformations was successfully constructed. The solution state 1 H–NMR, ESI–MS spectrum studies, and UV titration experiments emphasize the robustness of this g–motif in solution. Additionally, we combined the methods of single-crystal and solution-, solid-state CD spectrum together to discuss the chirality of the complexes. The complexes containing the g–motif structure, which reduces the energy of the system, following the solid-state CD signals, generally move in the long-wave direction. These results provided a new mismatched base pairing, that is g–motif. The interaction mode and full characterizations of g–motif will contribute to the study of the mismatched DNA interaction." @default.
• W3176367787 created "2021-07-05" @default.
• W3176367787 creator A5006867634 @default.
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• W3176367787 date "2021-06-30" @default.
• W3176367787 modified "2023-10-14" @default.
• W3176367787 title "The Research of G–Motif Construction and Chirality in Deoxyguanosine Monophosphate Nucleotide Complexes" @default.
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• W3176367787 doi "https://doi.org/10.3389/fchem.2021.709777" @default.
• W3176367787 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8278404" @default.
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