FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3176394408> ?p ?o ?g. }

• W3176394408 endingPage "2384" @default.
• W3176394408 startingPage "2374" @default.
• W3176394408 abstract "To investigate if short-term treatment with liraglutide, a glucagon-like peptide-1 receptor agonist, improves left ventricular diastolic function.An investigator-initiated, double-blind, randomized, placebo-controlled trial on the effect of 18 weeks of treatment with liraglutide on diastolic function was assessed in patients with type 2 diabetes with signs of diastolic dysfunction (echo-Doppler determined E/e' ≥ 9 and/or lateral e' ≤ 10 cm/s). Primary outcomes were improved left ventricle filling (the early peak filling rate [ePFR]) and left atrium ease of emptying (the passive emptying fraction [LAPEF ]), assessed by cardiac magnetic resonance imaging at rest and during chronotropic stress. Secondary outcomes included left ventricular and left atrial volumes and systolic function, measures of aortic stiffness and echocardiographic diastolic variables.Forty patients were randomized to liraglutide subcutaneously 1.8 mg/day (n = 20) or placebo (n = 20). Liraglutide reduced HbA1c (-0.47%, 95% CI [-0.88% to -0.06%] [-5.1, 95% CI {-9.7 to -0.62} mmol/mol]) and weight (-2.9, 95% CI [-4.6 to -1.2] kg); both P < .03. Liraglutide did not change ePFR at rest (-24 ± 60 vs. -6 ± 46 mL/s), during stress (2 ± 58 vs. -2 ± 38 mL/s), or the changes from rest to stress (12.9 ± 72.5 vs. 4.7 ± 104.0; all P > .05). LAPEF decreased with liraglutide during stress (-3.1% [-9.0%, 1.1%] vs. 1.0% [-2.9%, 6.1%]; P = .049), but no changes were evident at rest (-4.3% [-7.9%, 1.9%] vs. -0.6% [-3.1%, 2.2%]; P = .19), or for the changes from rest to stress (-1.7 ± 8.4 vs. 0.8 ± 8.2; P = .4). Secondary outcomes were unchanged by liraglutide.Short-term treatment with liraglutide did not improve left ventricular diastolic function, suggesting the cardioprotective effect is not exerted through the improvement in diastolic dysfunction." @default.
• W3176394408 created "2021-07-05" @default.
• W3176394408 creator A5007554380 @default.
• W3176394408 creator A5042890915 @default.
• W3176394408 creator A5042987831 @default.
• W3176394408 creator A5052571062 @default.
• W3176394408 creator A5077078738 @default.
• W3176394408 creator A5090909453 @default.
• W3176394408 date "2021-07-26" @default.
• W3176394408 modified "2023-10-16" @default.
• W3176394408 title "Metabolic improvement with short‐term, glucagon‐like peptide‐1 receptor agonist treatment does not improve cardiac diastolic dysfunction in patients with type 2 diabetes: A randomized, double‐blind, placebo‐controlled trial" @default.
• W3176394408 cites W1926344403 @default.
• W3176394408 cites W1963542379 @default.
• W3176394408 cites W1983000201 @default.
• W3176394408 cites W2005003893 @default.
• W3176394408 cites W2014051267 @default.
• W3176394408 cites W2037635895 @default.
• W3176394408 cites W2056527924 @default.
• W3176394408 cites W2070676046 @default.
• W3176394408 cites W2082743257 @default.
• W3176394408 cites W2094733735 @default.
• W3176394408 cites W2124664068 @default.
• W3176394408 cites W2132647844 @default.
• W3176394408 cites W2141222928 @default.
• W3176394408 cites W2141971513 @default.
• W3176394408 cites W2150959326 @default.
• W3176394408 cites W2154595662 @default.
• W3176394408 cites W2268647522 @default.
• W3176394408 cites W2321437416 @default.
• W3176394408 cites W2346769585 @default.
• W3176394408 cites W2425644022 @default.
• W3176394408 cites W2444268874 @default.
• W3176394408 cites W2471327176 @default.
• W3176394408 cites W2474423175 @default.
• W3176394408 cites W2482030508 @default.
• W3176394408 cites W2586303576 @default.
• W3176394408 cites W2625188121 @default.
• W3176394408 cites W2770135881 @default.
• W3176394408 cites W2773067288 @default.
• W3176394408 cites W2782989965 @default.
• W3176394408 cites W2946264273 @default.
• W3176394408 cites W2950259371 @default.
• W3176394408 cites W2979965402 @default.
• W3176394408 cites W2992821646 @default.
• W3176394408 cites W3094526132 @default.
• W3176394408 cites W3121027668 @default.
• W3176394408 doi "https://doi.org/10.1111/dom.14480" @default.
• W3176394408 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34189832" @default.
• W3176394408 hasPublicationYear "2021" @default.
• W3176394408 type Work @default.
• W3176394408 sameAs 3176394408 @default.
• W3176394408 citedByCount "5" @default.
• W3176394408 countsByYear W31763944082022 @default.
• W3176394408 countsByYear W31763944082023 @default.
• W3176394408 crossrefType "journal-article" @default.
• W3176394408 hasAuthorship W3176394408A5007554380 @default.
• W3176394408 hasAuthorship W3176394408A5042890915 @default.
• W3176394408 hasAuthorship W3176394408A5042987831 @default.
• W3176394408 hasAuthorship W3176394408A5052571062 @default.
• W3176394408 hasAuthorship W3176394408A5077078738 @default.
• W3176394408 hasAuthorship W3176394408A5090909453 @default.
• W3176394408 hasConcept C126322002 @default.
• W3176394408 hasConcept C134018914 @default.
• W3176394408 hasConcept C142724271 @default.
• W3176394408 hasConcept C164705383 @default.
• W3176394408 hasConcept C204787440 @default.
• W3176394408 hasConcept C27081682 @default.
• W3176394408 hasConcept C2777180221 @default.
• W3176394408 hasConcept C2778198053 @default.
• W3176394408 hasConcept C2778921608 @default.
• W3176394408 hasConcept C2781308992 @default.
• W3176394408 hasConcept C555293320 @default.
• W3176394408 hasConcept C57900726 @default.
• W3176394408 hasConcept C71924100 @default.
• W3176394408 hasConcept C78085059 @default.
• W3176394408 hasConcept C84393581 @default.
• W3176394408 hasConceptScore W3176394408C126322002 @default.
• W3176394408 hasConceptScore W3176394408C134018914 @default.
• W3176394408 hasConceptScore W3176394408C142724271 @default.
• W3176394408 hasConceptScore W3176394408C164705383 @default.
• W3176394408 hasConceptScore W3176394408C204787440 @default.
• W3176394408 hasConceptScore W3176394408C27081682 @default.
• W3176394408 hasConceptScore W3176394408C2777180221 @default.
• W3176394408 hasConceptScore W3176394408C2778198053 @default.
• W3176394408 hasConceptScore W3176394408C2778921608 @default.
• W3176394408 hasConceptScore W3176394408C2781308992 @default.
• W3176394408 hasConceptScore W3176394408C555293320 @default.
• W3176394408 hasConceptScore W3176394408C57900726 @default.
• W3176394408 hasConceptScore W3176394408C71924100 @default.
• W3176394408 hasConceptScore W3176394408C78085059 @default.
• W3176394408 hasConceptScore W3176394408C84393581 @default.
• W3176394408 hasFunder F4320309763 @default.
• W3176394408 hasFunder F4320322436 @default.
• W3176394408 hasIssue "10" @default.
• W3176394408 hasLocation W31763944081 @default.
• W3176394408 hasLocation W31763944082 @default.
• W3176394408 hasOpenAccess W3176394408 @default.
• W3176394408 hasPrimaryLocation W31763944081 @default.

• next