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- W3176475166 abstract "Abstract Despite poor graft integration among some patients that undergo an anterior cruciate ligament (ACL) reconstruction, there has been little consideration of the bone quality into which the ACL femoral tunnel is drilled and the graft is placed. Bone mineral density of the knee decreases following ACL injury. However, trabecular and cortical architecture differences between injured and non‐injured femoral ACL entheses have not been reported. We hypothesize that injured femoral ACL entheses will show significantly less cortical and trabecular mass compared with non‐injured controls. Femoral ACL enthesis explants from 54 female patients (13–25 years) were collected during ACL reconstructive surgery. Control explants ( n = 12) were collected from seven donors (18−36 years). Injured (I) femoral explants differed from those of non‐injured (NI) controls with significantly less ( p ≤ 0.001) cortical volumetric bone mineral density (vBMD) (NI: 736.1–867.6 mg/cm 3 ; I: 451.2–891.9 mg/cm 3 ), relative bone volume (BV/TV) (NI: 0.674–0.867; I: 0.401–0.792) and porosity (Ct.Po) (NI: 0.133–0.326; I: 0.209–0.600). Injured explants showed significantly less trabecular vBMD ( p = 0.013) but not trabecular BV/TV ( p = 0.314), thickness ( p = 0.412), or separation ( p = 0.828). We found significantly less cortical bone within injured femoral entheses compared to NI controls. Lower cortical and trabecular bone mass within patient femoral ACL entheses may help explain poor ACL graft osseointegration outcomes in the young and may be a contributor to the osteolytic phenomenon that often occurs within the graft tunnel following ACL reconstruction." @default.
- W3176475166 created "2021-07-05" @default.
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- W3176475166 date "2021-07-11" @default.
- W3176475166 modified "2023-10-15" @default.
- W3176475166 title "State of the mineralized tissue comprising the femoral ACL enthesis in young women with an ACL failure" @default.
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- W3176475166 doi "https://doi.org/10.1002/jor.25130" @default.
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