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- W3176482217 abstract "Mammalian hibernation is a response to periods of low temperature and limited food availability. The GI tract of hibernators undergoes significant physiological changes. Recent studies have found shifts in the microbial populations inhabiting the cecum during hibernation. We used immunoblotting to examine the expression of Toll-like receptors (TLRs) in the cecum of summer, hibernating and spring ground squirrels. TLR4 expression decreased during the hibernation season with the lowest levels found in squirrels that had been hibernating at least 3 months (late-season hibernators). TLR5 expression showed the opposite trend with increased expression in late-season hibernators compared to summer. Levels of TLR5 in spring squirrels were similar to summer, but TLR4 was similar to late-season hibernators. Expression of both TLRs did not differ between torpid and aroused hibernators at the same point in the season (early versus late). Together, these results suggest that hibernation induces changes in microbial sensing, perhaps as a result of increased permeability of the GI epithelium and shifts in the composition of the microbiota. Supported by UW-Oshkosh Student-Faculty Collaborative Grant Program." @default.
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- W3176482217 date "2013-04-01" @default.
- W3176482217 modified "2023-09-27" @default.
- W3176482217 title "Differential Expression of Toll‐like Receptors in the Cecum of Hibernating Ground Squirrels" @default.
- W3176482217 doi "https://doi.org/10.1096/fasebj.27.1_supplement.937.22" @default.
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