FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3176528963> ?p ?o ?g. }

• W3176528963 abstract "Background: Vascular injury has been implicated as a major cause of clinical complications in patients with coronavirus disease 2019 (COVID-19) based on autopsy studies showing destruction of the endothelial architecture. Red blood cells (RBCs) are affected by COVID-19 with alterations in their structure and function, possibly altering disease progress. Objectives: This study was designed to test the hypothesis of persistent endothelial dysfunction and that RBCs act as mediators of endothelial dysfunction in COVID-19. Methods and results: COVID-19 patients displayed profound endothelial dysfunction in vivo assessed with pulse amplitude tonometry, both in the acute phase and at follow-up four months later. RBCs from COVID-19 patients in the acute phase incubated with healthy rat aorta induced severe endothelial dysfunction ex vivo compared to RBCs from healthy subjects. Further, these RBCs induced upregulation of vascular arginase 1 and oxidative stress. Consequently, inhibition of vascular arginase or superoxide attenuated endothelial dysfunction induced by RBCs from COVID-19 patients. These RBCs were characterized by increased production of reactive oxygen species and reduced export of the nitric oxide metabolite nitrate. RBCs from COVID-19 patients at follow-up did not affect endothelial function. Pre-incubation of RBCs from healthy subjects with interferon-γ impaired endothelial function.Conclusions: This study demonstrates the presence of persistent endothelial dysfunction in an otherwise mainly healthy population hospitalized for COVID-19, and clearly implicates a central role of RBCs as mediators of endothelial injury. These data shed light on a new pathological mechanism underlying vascular dysfunction in COVID-19 and may lay the foundation for future therapeutic developments." @default.
• W3176528963 created "2021-07-05" @default.
• W3176528963 creator A5005914730 @default.
• W3176528963 creator A5012091863 @default.
• W3176528963 creator A5032433287 @default.
• W3176528963 creator A5049720596 @default.
• W3176528963 creator A5050380848 @default.
• W3176528963 creator A5063628549 @default.
• W3176528963 creator A5071232185 @default.
• W3176528963 creator A5074004090 @default.
• W3176528963 creator A5074123834 @default.
• W3176528963 creator A5079244052 @default.
• W3176528963 creator A5086508722 @default.
• W3176528963 creator A5089958949 @default.
• W3176528963 date "2021-01-01" @default.
• W3176528963 modified "2023-10-01" @default.
• W3176528963 title "Erythrocytes Induce Vascular Dysfunction in COVID-19" @default.
• W3176528963 cites W1985469097 @default.
• W3176528963 cites W2000851646 @default.
• W3176528963 cites W2088907497 @default.
• W3176528963 cites W2098430882 @default.
• W3176528963 cites W2134566930 @default.
• W3176528963 cites W2141421288 @default.
• W3176528963 cites W2302528395 @default.
• W3176528963 cites W2532544513 @default.
• W3176528963 cites W2807015102 @default.
• W3176528963 cites W2887906685 @default.
• W3176528963 cites W2949515295 @default.
• W3176528963 cites W2983279384 @default.
• W3176528963 cites W3015197361 @default.
• W3176528963 cites W3016595631 @default.
• W3176528963 cites W3017125154 @default.
• W3176528963 cites W3027918021 @default.
• W3176528963 cites W3047009938 @default.
• W3176528963 cites W3082240102 @default.
• W3176528963 cites W3088592513 @default.
• W3176528963 cites W3089936348 @default.
• W3176528963 cites W3093015530 @default.
• W3176528963 cites W3094409141 @default.
• W3176528963 cites W3111775269 @default.
• W3176528963 cites W3121071822 @default.
• W3176528963 cites W3121940444 @default.
• W3176528963 cites W3133670868 @default.
• W3176528963 cites W3135720498 @default.
• W3176528963 cites W3146299617 @default.
• W3176528963 doi "https://doi.org/10.2139/ssrn.3945298" @default.
• W3176528963 hasPublicationYear "2021" @default.
• W3176528963 type Work @default.
• W3176528963 sameAs 3176528963 @default.
• W3176528963 citedByCount "1" @default.
• W3176528963 countsByYear W31765289632022 @default.
• W3176528963 crossrefType "journal-article" @default.
• W3176528963 hasAuthorship W3176528963A5005914730 @default.
• W3176528963 hasAuthorship W3176528963A5012091863 @default.
• W3176528963 hasAuthorship W3176528963A5032433287 @default.
• W3176528963 hasAuthorship W3176528963A5049720596 @default.
• W3176528963 hasAuthorship W3176528963A5050380848 @default.
• W3176528963 hasAuthorship W3176528963A5063628549 @default.
• W3176528963 hasAuthorship W3176528963A5071232185 @default.
• W3176528963 hasAuthorship W3176528963A5074004090 @default.
• W3176528963 hasAuthorship W3176528963A5074123834 @default.
• W3176528963 hasAuthorship W3176528963A5079244052 @default.
• W3176528963 hasAuthorship W3176528963A5086508722 @default.
• W3176528963 hasAuthorship W3176528963A5089958949 @default.
• W3176528963 hasConcept C116675565 @default.
• W3176528963 hasConcept C126322002 @default.
• W3176528963 hasConcept C159047783 @default.
• W3176528963 hasConcept C164705383 @default.
• W3176528963 hasConcept C2779134260 @default.
• W3176528963 hasConcept C3006700255 @default.
• W3176528963 hasConcept C3007834351 @default.
• W3176528963 hasConcept C3008058167 @default.
• W3176528963 hasConcept C524204448 @default.
• W3176528963 hasConcept C71924100 @default.
• W3176528963 hasConceptScore W3176528963C116675565 @default.
• W3176528963 hasConceptScore W3176528963C126322002 @default.
• W3176528963 hasConceptScore W3176528963C159047783 @default.
• W3176528963 hasConceptScore W3176528963C164705383 @default.
• W3176528963 hasConceptScore W3176528963C2779134260 @default.
• W3176528963 hasConceptScore W3176528963C3006700255 @default.
• W3176528963 hasConceptScore W3176528963C3007834351 @default.
• W3176528963 hasConceptScore W3176528963C3008058167 @default.
• W3176528963 hasConceptScore W3176528963C524204448 @default.
• W3176528963 hasConceptScore W3176528963C71924100 @default.
• W3176528963 hasLocation W31765289631 @default.
• W3176528963 hasOpenAccess W3176528963 @default.
• W3176528963 hasPrimaryLocation W31765289631 @default.
• W3176528963 hasRelatedWork W3009669391 @default.
• W3176528963 hasRelatedWork W3036314732 @default.
• W3176528963 hasRelatedWork W3127693599 @default.
• W3176528963 hasRelatedWork W3198183218 @default.
• W3176528963 hasRelatedWork W4200329650 @default.
• W3176528963 hasRelatedWork W4205317059 @default.
• W3176528963 hasRelatedWork W4206669628 @default.
• W3176528963 hasRelatedWork W4210401150 @default.
• W3176528963 hasRelatedWork W4382894326 @default.
• W3176528963 hasRelatedWork W3127156785 @default.
• W3176528963 isParatext "false" @default.
• W3176528963 isRetracted "false" @default.
• W3176528963 magId "3176528963" @default.

• next