FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3176564191> ?p ?o ?g. }

• W3176564191 endingPage "232596712110119" @default.
• W3176564191 startingPage "232596712110119" @default.
• W3176564191 abstract "Platelet-rich plasma (PRP) has gained attention as a therapeutic option for knee osteoarthritis; however, its efficacy varies widely. Leukocytes in PRP raise the concern of aggravating proinflammatory activity. To date, PRP has rarely been investigated with regard to leukocyte concentration.To provide clinical evidence of the intra-articular injection of PRPs containing different leukocyte concentrations.Systematic review; Level of evidence, 4.We systematically searched the MEDLINE, Embase, Cochrane Library, CINAHL, and Scopus databases. PRP was classified into leukocyte-poor (LP-PRP) and leukocyte-rich (LR-PRP). Clinical outcomes including Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), visual analog scale (VAS) for pain score, International Knee Documentation Committee (IKDC) subjective score, and adverse reactions were evaluated. The Methodological Index for Non-Randomized Studies criteria were used for quality assessment.Included were 32 studies with an evidence level between 1 and 4. Both LP-PRP and LR-PRP showed improvements above the minimal clinically important difference (MCID) in VAS pain score. No significant intergroup difference was seen at 3, 6, or 12 months of follow-up. Regarding function, both LP-PRP and LR-PRP showed improvements above the MCID in the WOMAC and IKDC scores, with no significant difference between the groups. Adverse reactions for pain were significantly higher in LR-PRP than in LP-PRP (odds ratio, 1.64; 95% confidence interval, 1.29-2.10; P = .01). After intra-articular PRP injection, LR-PRP showed a significantly higher rate of swelling than LP-PRP (odds ratio, 1.56; 95% confidence interval, 1.22-1.99; P = .02). The mean Methodological Index for Non-Randomized Studies score of the included studies was 18.6 (range, 10-24).Intra-articular PRP injection resulted in improvements above the MCID in terms of pain and function in patients with knee osteoarthritis up to 12 months. The risk of local adverse reactions appeared to be increased after LR-PRP compared with LP-PRP injection. The findings of this review can support the potential use of intra-articular PRP injection for the treatment of knee osteoarthritis. In clinical application, clinicians need to consider selecting a specific type of PRP for knee osteoarthritis." @default.
• W3176564191 created "2021-07-05" @default.
• W3176564191 creator A5002118713 @default.
• W3176564191 creator A5029605633 @default.
• W3176564191 creator A5052320833 @default.
• W3176564191 creator A5064665637 @default.
• W3176564191 creator A5073586093 @default.
• W3176564191 date "2021-06-01" @default.
• W3176564191 modified "2023-10-01" @default.
• W3176564191 title "Adverse Reactions and Clinical Outcomes for Leukocyte-Poor Versus Leukocyte-Rich Platelet-Rich Plasma in Knee Osteoarthritis: A Systematic Review and Meta-analysis" @default.
• W3176564191 cites W1031259716 @default.
• W3176564191 cites W1716794597 @default.
• W3176564191 cites W1972124526 @default.
• W3176564191 cites W1977106770 @default.
• W3176564191 cites W1981688423 @default.
• W3176564191 cites W1989312946 @default.
• W3176564191 cites W1997719795 @default.
• W3176564191 cites W2003350056 @default.
• W3176564191 cites W2006113857 @default.
• W3176564191 cites W2008214282 @default.
• W3176564191 cites W2016774778 @default.
• W3176564191 cites W2017044005 @default.
• W3176564191 cites W2019271808 @default.
• W3176564191 cites W2020020571 @default.
• W3176564191 cites W2021423062 @default.
• W3176564191 cites W2021796223 @default.
• W3176564191 cites W2030322516 @default.
• W3176564191 cites W2047168227 @default.
• W3176564191 cites W2051796320 @default.
• W3176564191 cites W2064954118 @default.
• W3176564191 cites W2076891661 @default.
• W3176564191 cites W2079362390 @default.
• W3176564191 cites W2081189145 @default.
• W3176564191 cites W2086838304 @default.
• W3176564191 cites W2088653124 @default.
• W3176564191 cites W2096699701 @default.
• W3176564191 cites W2098923148 @default.
• W3176564191 cites W2099204150 @default.
• W3176564191 cites W2100200474 @default.
• W3176564191 cites W2102335423 @default.
• W3176564191 cites W2103946264 @default.
• W3176564191 cites W2104026153 @default.
• W3176564191 cites W2107641904 @default.
• W3176564191 cites W2108738802 @default.
• W3176564191 cites W2120771911 @default.
• W3176564191 cites W2123166289 @default.
• W3176564191 cites W2124433729 @default.
• W3176564191 cites W2125366323 @default.
• W3176564191 cites W2125605937 @default.
• W3176564191 cites W2129434064 @default.
• W3176564191 cites W2132844854 @default.
• W3176564191 cites W2139168999 @default.
• W3176564191 cites W2139382287 @default.
• W3176564191 cites W2139523975 @default.
• W3176564191 cites W2141157018 @default.
• W3176564191 cites W2143328793 @default.
• W3176564191 cites W2155663618 @default.
• W3176564191 cites W2161374186 @default.
• W3176564191 cites W2162321417 @default.
• W3176564191 cites W2164434561 @default.
• W3176564191 cites W2167432895 @default.
• W3176564191 cites W2170082773 @default.
• W3176564191 cites W2268253304 @default.
• W3176564191 cites W2268621357 @default.
• W3176564191 cites W2276644929 @default.
• W3176564191 cites W2327421967 @default.
• W3176564191 cites W2332793349 @default.
• W3176564191 cites W2502607126 @default.
• W3176564191 cites W2512636967 @default.
• W3176564191 cites W2525857977 @default.
• W3176564191 cites W2535103699 @default.
• W3176564191 cites W2563112167 @default.
• W3176564191 cites W2582002924 @default.
• W3176564191 cites W2582012588 @default.
• W3176564191 cites W2588369972 @default.
• W3176564191 cites W2588681363 @default.
• W3176564191 cites W2782530152 @default.
• W3176564191 cites W2790600717 @default.
• W3176564191 cites W2804451521 @default.
• W3176564191 cites W2884783263 @default.
• W3176564191 cites W2907286282 @default.
• W3176564191 cites W2910217725 @default.
• W3176564191 cites W2922052126 @default.
• W3176564191 cites W2946789586 @default.
• W3176564191 cites W2948016161 @default.
• W3176564191 cites W2965325848 @default.
• W3176564191 cites W330722923 @default.
• W3176564191 cites W4255768203 @default.
• W3176564191 doi "https://doi.org/10.1177/23259671211011948" @default.
• W3176564191 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8255589" @default.
• W3176564191 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34277879" @default.
• W3176564191 hasPublicationYear "2021" @default.
• W3176564191 type Work @default.
• W3176564191 sameAs 3176564191 @default.
• W3176564191 citedByCount "25" @default.
• W3176564191 countsByYear W31765641912022 @default.
• W3176564191 countsByYear W31765641912023 @default.
• W3176564191 crossrefType "journal-article" @default.

• next