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• W3176572062 endingPage "104974" @default.
• W3176572062 startingPage "104974" @default.
• W3176572062 abstract "Chitin synthesis inhibitors (CSI) are supposed to inhibit formation of chitin microfibrils in newly synthesized cuticle during molting process. Conversely, there has been comparatively few data on morphological effects of CSI on non-target insect organs. In this work, the effects of the CSI novaluron on behavior and midgut of A. aegypti were evaluated. Toxicity bioassays revealed that novaluron is toxic to A. aegypti larva with LC50 = 18.57 mg L-1 when exposed in aqueous solution for 24 h. Novaluron treated larvae were less active and spent more time resting compared to the control group. Histopathology showed that midguts of novaluron-treated larvae had cytoplasm vacuolization and damaged brush border. Cytotoxic effects in midguts of treated larvae induced necrosis, autophagy and damage to mitochondria. Despite being chitin synthesis inhibitor, novaluron did not induce alterations in the integument of A. aegypti larvae. Fluorescence microscopy revealed that the number of digestive cells were higher in novaluron-treated larvae than in control, in response to digestive cell apoptosis. The present study highlights the importance of novaluron against A. aegypti larvae by causing injuries to non-target organs, altering behaviors, inducing cell death and inhibiting cell proliferation." @default.
• W3176572062 created "2021-07-05" @default.
• W3176572062 creator A5023320845 @default.
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• W3176572062 date "2021-09-01" @default.
• W3176572062 modified "2023-10-17" @default.
• W3176572062 title "Behavioral and ultrastructural effects of novaluron on Aedes aegypti larvae" @default.
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• W3176572062 doi "https://doi.org/10.1016/j.meegid.2021.104974" @default.
• W3176572062 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34166815" @default.
• W3176572062 hasPublicationYear "2021" @default.
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