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• W3176586247 abstract "One-step mid- and far-Fourier-transform (FT)-IR spectroscopy is a facile and powerful tool that provides various information regarding chemical and crystal states. However, its potentially high applicability has not been sufficiently demonstrated. In the present study, ibuprofen (IB)-loaded MgO samples are prepared via different methods, and they are evaluated using scanning electron microscopy (SEM), thermogravimetry-differential thermal analysis (TG-DTA), X-ray diffraction analysis (XRD), N2 adsorption-desorption measurement, CO2 temperature-programmed desorption technique (CO2-TPD), and FT-IR spectroscopy. The obtained results indicate that IB becomes ionized, amorphous, and/or dispersed by using MgO. Since the CO2-TPD result shows that MgO possesses basic surfaces, it is considerable that acid–base interactions cause the above different chemical states. Furthermore, the FT-IR spectra in mid- and far-IR regions also suggest that the above physical and chemical properties of IB-loaded MgO changes through the interactions. Therefore, the characterization results suggest that one-step mid- and far-FT-IR measurements can provide valuable information regarding the chemical and crystal states." @default.
• W3176586247 created "2021-07-05" @default.
• W3176586247 creator A5073954252 @default.
• W3176586247 date "2021-07-01" @default.
• W3176586247 modified "2023-10-14" @default.
• W3176586247 title "Characterization of Ibuprofen-Loaded MgO by One-Step Mid- and Far-FT-IR Spectroscopy" @default.
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• W3176586247 doi "https://doi.org/10.1248/cpb.c20-00564" @default.
• W3176586247 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34193717" @default.
• W3176586247 hasPublicationYear "2021" @default.
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