FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3176608959> ?p ?o ?g. }

• W3176608959 endingPage "6948" @default.
• W3176608959 startingPage "6948" @default.
• W3176608959 abstract "Diffuse alveolar hemorrhage (DAH) in systemic lupus erythematosus (SLE) is associated with significant mortality, requiring a thorough understanding of its complex mechanisms to develop novel therapeutics for disease control. Activated p53-dependent apoptosis with dysregulated long non-coding RNA (lncRNA) expression is involved in the SLE pathogenesis and correlated with clinical activity. We examined the expression of apoptosis-related p53-dependent lncRNA, including H19, HOTAIR and lincRNA-p21 in SLE-associated DAH patients. Increased lincRNA-p21 levels were detected in circulating mononuclear cells, mainly in CD4+ and CD14+ cells. Higher expression of p53, lincRNA-p21 and cell apoptosis was identified in lung tissues. Lentivirus-based short hairpin RNA (shRNA)-transduced stable transfectants were created for examining the targeting efficacy in lncRNA. Under pristane stimulation, alveolar epithelial cells had increased p53, lincRNA-p21 and downstream Bax levels with elevated apoptotic ratios. After pristane injection, C57/BL6 mice developed DAH with increased pulmonary expression of p53, lincRNA-p21 and cell apoptosis. Intra-pulmonary delivery of shRNA targeting lincRNA-p21 reduced hemorrhage frequencies and improved anemia status through decreasing Bax expression and cell apoptosis. Our findings demonstrate increased p53-dependent lncRNA expression with accelerated cell apoptosis in the lungs of SLE-associated DAH patients, and show the therapeutic potential of targeting intra-pulmonary lncRNA expression in a pristane-induced model of DAH." @default.
• W3176608959 created "2021-07-05" @default.
• W3176608959 creator A5019982228 @default.
• W3176608959 creator A5022399152 @default.
• W3176608959 creator A5031921996 @default.
• W3176608959 creator A5033316100 @default.
• W3176608959 creator A5045917700 @default.
• W3176608959 creator A5047664460 @default.
• W3176608959 creator A5047696782 @default.
• W3176608959 creator A5074547202 @default.
• W3176608959 creator A5088441094 @default.
• W3176608959 date "2021-06-28" @default.
• W3176608959 modified "2023-10-01" @default.
• W3176608959 title "Targeting Intra-Pulmonary P53-Dependent Long Non-Coding RNA Expression as a Therapeutic Intervention for Systemic Lupus Erythematosus-Associated Diffuse Alveolar Hemorrhage" @default.
• W3176608959 cites W1539168190 @default.
• W3176608959 cites W1769569140 @default.
• W3176608959 cites W1929978039 @default.
• W3176608959 cites W1951304988 @default.
• W3176608959 cites W1971770319 @default.
• W3176608959 cites W1975075656 @default.
• W3176608959 cites W1984826562 @default.
• W3176608959 cites W1991133811 @default.
• W3176608959 cites W2023848400 @default.
• W3176608959 cites W2036917673 @default.
• W3176608959 cites W2037263078 @default.
• W3176608959 cites W2037999753 @default.
• W3176608959 cites W2038490089 @default.
• W3176608959 cites W2050359926 @default.
• W3176608959 cites W2052010787 @default.
• W3176608959 cites W2069853302 @default.
• W3176608959 cites W2070527591 @default.
• W3176608959 cites W2085929619 @default.
• W3176608959 cites W2107999308 @default.
• W3176608959 cites W2110861966 @default.
• W3176608959 cites W2111049806 @default.
• W3176608959 cites W2113764090 @default.
• W3176608959 cites W2124954743 @default.
• W3176608959 cites W2144285907 @default.
• W3176608959 cites W2149673968 @default.
• W3176608959 cites W2161280732 @default.
• W3176608959 cites W2163018106 @default.
• W3176608959 cites W2169488095 @default.
• W3176608959 cites W2334348774 @default.
• W3176608959 cites W2347080109 @default.
• W3176608959 cites W2479657593 @default.
• W3176608959 cites W2519552876 @default.
• W3176608959 cites W2519566455 @default.
• W3176608959 cites W2589030186 @default.
• W3176608959 cites W2615235559 @default.
• W3176608959 cites W2752364180 @default.
• W3176608959 cites W2791408070 @default.
• W3176608959 cites W2809048403 @default.
• W3176608959 cites W2859850329 @default.
• W3176608959 cites W2886766736 @default.
• W3176608959 cites W2900606837 @default.
• W3176608959 cites W2904749742 @default.
• W3176608959 cites W2927346670 @default.
• W3176608959 cites W2969256811 @default.
• W3176608959 cites W2970889749 @default.
• W3176608959 cites W2972660038 @default.
• W3176608959 cites W2980563841 @default.
• W3176608959 cites W2982711111 @default.
• W3176608959 cites W2990503088 @default.
• W3176608959 cites W2998499240 @default.
• W3176608959 cites W2999009728 @default.
• W3176608959 cites W3005836320 @default.
• W3176608959 cites W3020738022 @default.
• W3176608959 cites W3036046622 @default.
• W3176608959 cites W3036950099 @default.
• W3176608959 cites W3037718479 @default.
• W3176608959 cites W3087871887 @default.
• W3176608959 cites W3120377926 @default.
• W3176608959 cites W3139118826 @default.
• W3176608959 cites W3151358148 @default.
• W3176608959 doi "https://doi.org/10.3390/ijms22136948" @default.
• W3176608959 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8268786" @default.
• W3176608959 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34203338" @default.
• W3176608959 hasPublicationYear "2021" @default.
• W3176608959 type Work @default.
• W3176608959 sameAs 3176608959 @default.
• W3176608959 citedByCount "6" @default.
• W3176608959 countsByYear W31766089592022 @default.
• W3176608959 countsByYear W31766089592023 @default.
• W3176608959 crossrefType "journal-article" @default.
• W3176608959 hasAuthorship W3176608959A5019982228 @default.
• W3176608959 hasAuthorship W3176608959A5022399152 @default.
• W3176608959 hasAuthorship W3176608959A5031921996 @default.
• W3176608959 hasAuthorship W3176608959A5033316100 @default.
• W3176608959 hasAuthorship W3176608959A5045917700 @default.
• W3176608959 hasAuthorship W3176608959A5047664460 @default.
• W3176608959 hasAuthorship W3176608959A5047696782 @default.
• W3176608959 hasAuthorship W3176608959A5074547202 @default.
• W3176608959 hasAuthorship W3176608959A5088441094 @default.
• W3176608959 hasBestOaLocation W31766089591 @default.
• W3176608959 hasConcept C137061746 @default.
• W3176608959 hasConcept C173396325 @default.
• W3176608959 hasConcept C190232843 @default.
• W3176608959 hasConcept C190283241 @default.

• next