Matches in SemOpenAlex for { <https://semopenalex.org/work/W3176617646> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W3176617646 abstract "Background and Aim: Alcoholic Liver Disease (ALD), caused by longterm heavy alcohol consumption, is influenced by genetic factors. Studies have illustrated the overlapping genetic mechanism in Nonalcoholic Fatty Liver Disease (NAFLD) and ALD. Recently, a number of Genome-Wide Association Studies (GWAS) have demonstrated several SNPs were strongly associated with NAFLD. The aim of present study is to evaluate the association between these NAFLD-associated SNPs and ALD in Chinese Han population. Methods: Nine SNPs were selected and genotyped in a cohort of 507 patients with ALD and 645 healthy controls by using MassARRAY iPLEX system. Alleles and genotypes analysis of SNPs were performed in logistic regression. The association between SNP and the level of liver serum biomarkers was tested in chi-square test and linear regression model. Results: Our data confirmed that rs2281135 A-allele in PNPLA3 and rs3761472 G-allele in SAMM50 were significantly associated with increased risk of ALD (P = 1.93×10-12, OR [95% CI] = 1.82 [1.54-2.15]; P = 2.08×10-16, OR [95% CI] = 1.06 [1.04-1.08], respectively). The genotypes of rs2281135 were associated with ALD in additive, dominant and recessive genetic model (P = 1.24×10-11, P = 1.46×10-7, P = 2.07×10-9, respectively). In addition, rs2281135 was found to be associated with serum elevated levels of ALT (P = 5.0×10-3), AST (P = 0.03), ALP (P = 0.02), GGT (P = 0.03) in patients with ALD. Conclusions: The present study confirmed that PNPLA3 common variant rs2281135 was significantly associated with ALD in Chinese male Han population." @default.
- W3176617646 created "2021-07-05" @default.
- W3176617646 creator A5002051017 @default.
- W3176617646 creator A5013533184 @default.
- W3176617646 creator A5017397832 @default.
- W3176617646 creator A5035500131 @default.
- W3176617646 creator A5040326429 @default.
- W3176617646 creator A5046262151 @default.
- W3176617646 creator A5053709493 @default.
- W3176617646 creator A5061999874 @default.
- W3176617646 creator A5066794267 @default.
- W3176617646 creator A5078960489 @default.
- W3176617646 creator A5090921153 @default.
- W3176617646 date "2021-05-25" @default.
- W3176617646 modified "2023-09-25" @default.
- W3176617646 title "Association of Common Variant Rs2281135 of PNPLA3 with Alcohol-Related Cirrhosis in Chinese Han Males" @default.
- W3176617646 doi "https://doi.org/10.26420/austinjpathollabmed.2021.1033" @default.
- W3176617646 hasPublicationYear "2021" @default.
- W3176617646 type Work @default.
- W3176617646 sameAs 3176617646 @default.
- W3176617646 citedByCount "0" @default.
- W3176617646 crossrefType "journal-article" @default.
- W3176617646 hasAuthorship W3176617646A5002051017 @default.
- W3176617646 hasAuthorship W3176617646A5013533184 @default.
- W3176617646 hasAuthorship W3176617646A5017397832 @default.
- W3176617646 hasAuthorship W3176617646A5035500131 @default.
- W3176617646 hasAuthorship W3176617646A5040326429 @default.
- W3176617646 hasAuthorship W3176617646A5046262151 @default.
- W3176617646 hasAuthorship W3176617646A5053709493 @default.
- W3176617646 hasAuthorship W3176617646A5061999874 @default.
- W3176617646 hasAuthorship W3176617646A5066794267 @default.
- W3176617646 hasAuthorship W3176617646A5078960489 @default.
- W3176617646 hasAuthorship W3176617646A5090921153 @default.
- W3176617646 hasBestOaLocation W31766176461 @default.
- W3176617646 hasConcept C104317684 @default.
- W3176617646 hasConcept C106208931 @default.
- W3176617646 hasConcept C126322002 @default.
- W3176617646 hasConcept C135763542 @default.
- W3176617646 hasConcept C139275648 @default.
- W3176617646 hasConcept C153209595 @default.
- W3176617646 hasConcept C156957248 @default.
- W3176617646 hasConcept C180754005 @default.
- W3176617646 hasConcept C186413461 @default.
- W3176617646 hasConcept C2776954865 @default.
- W3176617646 hasConcept C2777214474 @default.
- W3176617646 hasConcept C2777575235 @default.
- W3176617646 hasConcept C2778772119 @default.
- W3176617646 hasConcept C2779134260 @default.
- W3176617646 hasConcept C2992519594 @default.
- W3176617646 hasConcept C54355233 @default.
- W3176617646 hasConcept C71924100 @default.
- W3176617646 hasConcept C72563966 @default.
- W3176617646 hasConcept C86803240 @default.
- W3176617646 hasConcept C90924648 @default.
- W3176617646 hasConceptScore W3176617646C104317684 @default.
- W3176617646 hasConceptScore W3176617646C106208931 @default.
- W3176617646 hasConceptScore W3176617646C126322002 @default.
- W3176617646 hasConceptScore W3176617646C135763542 @default.
- W3176617646 hasConceptScore W3176617646C139275648 @default.
- W3176617646 hasConceptScore W3176617646C153209595 @default.
- W3176617646 hasConceptScore W3176617646C156957248 @default.
- W3176617646 hasConceptScore W3176617646C180754005 @default.
- W3176617646 hasConceptScore W3176617646C186413461 @default.
- W3176617646 hasConceptScore W3176617646C2776954865 @default.
- W3176617646 hasConceptScore W3176617646C2777214474 @default.
- W3176617646 hasConceptScore W3176617646C2777575235 @default.
- W3176617646 hasConceptScore W3176617646C2778772119 @default.
- W3176617646 hasConceptScore W3176617646C2779134260 @default.
- W3176617646 hasConceptScore W3176617646C2992519594 @default.
- W3176617646 hasConceptScore W3176617646C54355233 @default.
- W3176617646 hasConceptScore W3176617646C71924100 @default.
- W3176617646 hasConceptScore W3176617646C72563966 @default.
- W3176617646 hasConceptScore W3176617646C86803240 @default.
- W3176617646 hasConceptScore W3176617646C90924648 @default.
- W3176617646 hasIssue "2" @default.
- W3176617646 hasLocation W31766176461 @default.
- W3176617646 hasOpenAccess W3176617646 @default.
- W3176617646 hasPrimaryLocation W31766176461 @default.
- W3176617646 hasRelatedWork W1511048503 @default.
- W3176617646 hasRelatedWork W1556506844 @default.
- W3176617646 hasRelatedWork W2030527465 @default.
- W3176617646 hasRelatedWork W2333335337 @default.
- W3176617646 hasRelatedWork W2395179498 @default.
- W3176617646 hasRelatedWork W2490436072 @default.
- W3176617646 hasRelatedWork W2782420711 @default.
- W3176617646 hasRelatedWork W2915032079 @default.
- W3176617646 hasRelatedWork W3200423548 @default.
- W3176617646 hasRelatedWork W659250666 @default.
- W3176617646 hasVolume "8" @default.
- W3176617646 isParatext "false" @default.
- W3176617646 isRetracted "false" @default.
- W3176617646 magId "3176617646" @default.
- W3176617646 workType "article" @default.