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- W3176649308 startingPage "158" @default.
- W3176649308 abstract "Cancer immunotherapy offers substantive benefit to patients with various tumour types, in some cases leading to complete tumour clearance. However, many patients do not respond to immunotherapy, galvanizing the field to define the mechanisms of pre-existing and acquired resistance. Interferon-γ (IFNγ) is a cytokine that has both protumour and antitumour activities, suggesting that it may serve as a nexus for responsiveness to immunotherapy. Many cancer immunotherapies and chemotherapies induce IFNγ production by various cell types, including activated T cells and natural killer cells. Patients resistant to these therapies commonly have molecular aberrations in the IFNγ signalling pathway or express resistance molecules driven by IFNγ. Given that all nucleated cells can respond to IFNγ, the functional consequences of IFNγ production need to be carefully dissected on a cell-by-cell basis. Here, we review the cells that produce IFNγ and the different effects of IFNγ in the tumour microenvironment, highlighting the pleiotropic nature of this multifunctional and abundant cytokine." @default.
- W3176649308 created "2021-07-05" @default.
- W3176649308 creator A5001000053 @default.
- W3176649308 creator A5008106149 @default.
- W3176649308 creator A5047331973 @default.
- W3176649308 date "2021-06-21" @default.
- W3176649308 modified "2023-10-17" @default.
- W3176649308 title "Interferon-γ: teammate or opponent in the tumour microenvironment?" @default.
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