FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3176674180> ?p ?o ?g. }

• W3176674180 endingPage "30" @default.
• W3176674180 startingPage "24" @default.
• W3176674180 abstract "Severe pain is among the most common and deleterious symptoms experienced by individuals with sickle cell disease (SCD), of whom more than 50% report chronic pain. Despite this, the understanding of the biological contributors to persistent severe SCD pain is limited. This exploratory study sought to describe pain phenotypes based on frequency of severe pain experienced over 6 months and identify inflammatory biomarkers associated with pain phenotypes among individuals with SCD.This study used self-report and electronic health record data collected from 74 individuals enrolled in the Duke Sickle Cell Disease Implementation Consortium Registry. Plasma from previously collected blood specimens was used to generate inflammatory biomarker data using the Inflammation 20-plex ProcartaPlexTM panel. Descriptive statistics were used to describe the occurrence of severe pain over the past 6 months, and bi-variate analyses were used to evaluate the relationship between inflammatory biomarkers and pain phenotypes.Among the 74 participants included in this study, 33.8% reported severe pain occurring never or rarely, 40.5% reported severe pain occurring sometimes, and 25.7% reported severe pain occurring often or always. Soluble E-selectin (sE-selectin) was the only inflammatory biomarker significantly associated with the pain phenotype groups (p = 0.049). Post hoc comparisons identified that participants in the often/always severe pain group had significantly higher plasma concentrations of sE-selectin compared to those in the sometimes severe pain group (p = 0.040).Our findings provide preliminary evidence of the frequent occurrence of severe pain and that sE-selectin may be an objective biomarker for the frequent occurrence of severe pain in this population." @default.
• W3176674180 created "2021-07-05" @default.
• W3176674180 creator A5009941414 @default.
• W3176674180 creator A5031691140 @default.
• W3176674180 creator A5039303056 @default.
• W3176674180 creator A5065338156 @default.
• W3176674180 creator A5083173795 @default.
• W3176674180 date "2021-06-30" @default.
• W3176674180 modified "2023-09-29" @default.
• W3176674180 title "Severe Persistent Pain and Inflammatory Biomarkers in Sickle Cell Disease: An Exploratory Study" @default.
• W3176674180 cites W1526630390 @default.
• W3176674180 cites W1604761302 @default.
• W3176674180 cites W187221286 @default.
• W3176674180 cites W1873662028 @default.
• W3176674180 cites W1924703325 @default.
• W3176674180 cites W1964235253 @default.
• W3176674180 cites W1983297963 @default.
• W3176674180 cites W2012768600 @default.
• W3176674180 cites W2022387905 @default.
• W3176674180 cites W2026063712 @default.
• W3176674180 cites W2030486359 @default.
• W3176674180 cites W2036246029 @default.
• W3176674180 cites W2043340279 @default.
• W3176674180 cites W2048066714 @default.
• W3176674180 cites W2059396054 @default.
• W3176674180 cites W2062693222 @default.
• W3176674180 cites W2084545751 @default.
• W3176674180 cites W2089653299 @default.
• W3176674180 cites W2119337283 @default.
• W3176674180 cites W2126649096 @default.
• W3176674180 cites W2131868847 @default.
• W3176674180 cites W2157735478 @default.
• W3176674180 cites W2171783221 @default.
• W3176674180 cites W2303236807 @default.
• W3176674180 cites W2324965719 @default.
• W3176674180 cites W2571379331 @default.
• W3176674180 cites W2584759769 @default.
• W3176674180 cites W2599692870 @default.
• W3176674180 cites W2606799890 @default.
• W3176674180 cites W2621335789 @default.
• W3176674180 cites W2747938450 @default.
• W3176674180 cites W2749349218 @default.
• W3176674180 cites W2770410518 @default.
• W3176674180 cites W2786697307 @default.
• W3176674180 cites W2794850401 @default.
• W3176674180 cites W2795151943 @default.
• W3176674180 cites W2800110281 @default.
• W3176674180 cites W2889700593 @default.
• W3176674180 cites W2891034193 @default.
• W3176674180 cites W2894425242 @default.
• W3176674180 cites W2898014977 @default.
• W3176674180 cites W2945537500 @default.
• W3176674180 cites W3012264214 @default.
• W3176674180 cites W3016533212 @default.
• W3176674180 cites W3042176546 @default.
• W3176674180 cites W3161157714 @default.
• W3176674180 cites W50134281 @default.
• W3176674180 doi "https://doi.org/10.1177/10998004211027220" @default.
• W3176674180 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34189962" @default.
• W3176674180 hasPublicationYear "2021" @default.
• W3176674180 type Work @default.
• W3176674180 sameAs 3176674180 @default.
• W3176674180 citedByCount "2" @default.
• W3176674180 countsByYear W31766741802022 @default.
• W3176674180 countsByYear W31766741802023 @default.
• W3176674180 crossrefType "journal-article" @default.
• W3176674180 hasAuthorship W3176674180A5009941414 @default.
• W3176674180 hasAuthorship W3176674180A5031691140 @default.
• W3176674180 hasAuthorship W3176674180A5039303056 @default.
• W3176674180 hasAuthorship W3176674180A5065338156 @default.
• W3176674180 hasAuthorship W3176674180A5083173795 @default.
• W3176674180 hasBestOaLocation W31766741802 @default.
• W3176674180 hasConcept C126322002 @default.
• W3176674180 hasConcept C185592680 @default.
• W3176674180 hasConcept C1862650 @default.
• W3176674180 hasConcept C2779134260 @default.
• W3176674180 hasConcept C2781118164 @default.
• W3176674180 hasConcept C2781197716 @default.
• W3176674180 hasConcept C55493867 @default.
• W3176674180 hasConcept C71924100 @default.
• W3176674180 hasConceptScore W3176674180C126322002 @default.
• W3176674180 hasConceptScore W3176674180C185592680 @default.
• W3176674180 hasConceptScore W3176674180C1862650 @default.
• W3176674180 hasConceptScore W3176674180C2779134260 @default.
• W3176674180 hasConceptScore W3176674180C2781118164 @default.
• W3176674180 hasConceptScore W3176674180C2781197716 @default.
• W3176674180 hasConceptScore W3176674180C55493867 @default.
• W3176674180 hasConceptScore W3176674180C71924100 @default.
• W3176674180 hasFunder F4320332161 @default.
• W3176674180 hasIssue "1" @default.
• W3176674180 hasLocation W31766741801 @default.
• W3176674180 hasLocation W31766741802 @default.
• W3176674180 hasLocation W31766741803 @default.
• W3176674180 hasOpenAccess W3176674180 @default.
• W3176674180 hasPrimaryLocation W31766741801 @default.
• W3176674180 hasRelatedWork W1963672760 @default.
• W3176674180 hasRelatedWork W2064219387 @default.
• W3176674180 hasRelatedWork W2119974004 @default.

• next