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• W3176681856 abstract "Background Muscle sympathetic nerve activity (MSNA) is augmented in patients with sleep apnea. This increase in activity is due to increases in firing probability and mean firing rates of individual vasoconstrictor neurons, in addition to multiple within-burst firing; however, contributing mechanisms and the impact of such firing patterns on peripheral vascular tone are less clear. We examined the effect of acute intermittent hypoxia (IH) on sympathetic neural firing and recruitment strategies and the relationship between changes in MSNA and neurovascular transduction following acute IH. We hypothesized exposure to acute IH would increase MSNA via an increase in action potential (AP) discharge rates and within-burst firing. We further hypothesized any change in discharge patterns following acute IH would be positively related to a change in neurovascular transduction. Methods Blood pressure (brachial arterial catheter) and MSNA (microneurography of the peroneal nerve) were assessed in 17 healthy adults (11M/6F; 31 ± 1 yrs) during quiet normoxic rest prior to and following 30-min of experimental IH [30-s hypoxic (0.05 FiO2) exposures alternating with 90-s room air breathing]. AP patterns were studied from the filtered raw MSNA signal using wavelet-based methodology. The slope of the relationship between diastolic blood pressure (DBP) and the preceding MSNA burst area at a fixed cardiac cycle lag was used to quantify neurovascular transduction. Results IH resulted in 15 events where oxygen saturation was reduced (SpO2: 99 ± 1% vs 92 ± 1%, P<0.01). Compared to baseline, multi-unit MSNA burst incidence (33 ± 4 to 43 ± 5 bursts/100 heart beats), AP incidence (272 ± 50 to 501 ± 112 AP/100 heart beats) and AP content per integrated burst (7 ± 1 to 10 ± 1 AP/burst; 4 ± 1 to 5 ± 1 clusters/burst) were increased following IH (all P<0.05). Neurovascular transduction was not altered following IH (P=0.34); however, there was a positive relationship between the change (Δ) in neurovascular transduction (mmHg/%/s) and changes in AP discharge rate (AP/100 heart beats; R=0.52, P=0.03) and within-burst firing (AP/burst; R=0.38, P=0.14) following IH. Conclusions Acute IH increases sympathetic neuronal discharge by increasing within-burst firing of low-threshold axons. A positive relationship exists between increases in the neural discharge rates and neurovascular transduction following acute IH, such that those individuals with the greatest increase in AP firing exhibited the greatest increase in transduction of sympathetic activity into blood pressure. These data may have important implications for mechanistic understanding of sympathetic activation in sleep apnea and its down-stream effects, including the development of hypertension and cardiovascular disease. Support or Funding Information Funding: NIH HL130339, Mayo Clinic Center for Biomedical Discovery, Mizzou HES PURE, APS UGSRF. This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal." @default.
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• W3176681856 date "2019-04-01" @default.
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• W3176681856 title "Sympathetic Discharge Patterns and Neurovascular Transduction Following Acute Intermittent Hypoxia" @default.
• W3176681856 doi "https://doi.org/10.1096/fasebj.2019.33.1_supplement.562.8" @default.
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