FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3176706054> ?p ?o ?g. }

• W3176706054 endingPage "573" @default.
• W3176706054 startingPage "554" @default.
• W3176706054 abstract "Abstract Regional iron accumulation and α‐synuclein (α‐syn) spreading pathology within the central nervous system are common pathological findings in Parkinson's disease (PD). Whereas iron is known to bind to α‐syn, facilitating its aggregation and regulating α‐syn expression, it remains unclear if and how iron also modulates α‐syn spreading. To elucidate the influence of iron on the propagation of α‐syn pathology, we investigated α‐syn spreading after stereotactic injection of α‐syn preformed fibrils (PFFs) into the striatum of mouse brains after neonatal brain iron enrichment. C57Bl/6J mouse pups received oral gavage with 60, 120, or 240 mg/kg carbonyl iron or vehicle between postnatal days 10 and 17. At 12 weeks of age, intrastriatal injections of 5‐µg PFFs were performed to induce seeding of α‐syn aggregates. At 90 days post‐injection, PFFs‐injected mice displayed long‐term memory deficits, without affection of motor behavior. Interestingly, quantification of α‐syn phosphorylated at S129 showed reduced α‐syn pathology and attenuated spreading to connectome‐specific brain regions after brain iron enrichment. Furthermore, PFFs injection caused intrastriatal microglia accumulation, which was alleviated by iron in a dose‐dependent way. In primary cortical neurons in a microfluidic chamber model in vitro, iron application did not alter trans‐synaptic α‐syn propagation, possibly indicating an involvement of non‐neuronal cells in this process. Our study suggests that α‐syn PFFs may induce cognitive deficits in mice independent of iron. However, a redistribution of α‐syn aggregate pathology and reduction of striatal microglia accumulation in the mouse brain may be mediated via iron‐induced alterations of the brain connectome. image" @default.
• W3176706054 created "2021-07-05" @default.
• W3176706054 creator A5002822653 @default.
• W3176706054 creator A5003936132 @default.
• W3176706054 creator A5016418059 @default.
• W3176706054 creator A5017401077 @default.
• W3176706054 creator A5018138421 @default.
• W3176706054 creator A5033249566 @default.
• W3176706054 creator A5050687402 @default.
• W3176706054 creator A5053690690 @default.
• W3176706054 creator A5057435795 @default.
• W3176706054 creator A5061221445 @default.
• W3176706054 creator A5067307365 @default.
• W3176706054 creator A5076653713 @default.
• W3176706054 creator A5080600182 @default.
• W3176706054 creator A5091824690 @default.
• W3176706054 date "2021-08-02" @default.
• W3176706054 modified "2023-10-15" @default.
• W3176706054 title "Brain iron enrichment attenuates α‐synuclein spreading after injection of preformed fibrils" @default.
• W3176706054 cites W1496790952 @default.
• W3176706054 cites W1514250374 @default.
• W3176706054 cites W1890963973 @default.
• W3176706054 cites W1906155463 @default.
• W3176706054 cites W1965095016 @default.
• W3176706054 cites W1967640115 @default.
• W3176706054 cites W1975389666 @default.
• W3176706054 cites W1979987809 @default.
• W3176706054 cites W1984962080 @default.
• W3176706054 cites W1984974501 @default.
• W3176706054 cites W1986782185 @default.
• W3176706054 cites W1990309817 @default.
• W3176706054 cites W1992566356 @default.
• W3176706054 cites W1995191747 @default.
• W3176706054 cites W2002369606 @default.
• W3176706054 cites W2003181166 @default.
• W3176706054 cites W2004261895 @default.
• W3176706054 cites W2004628001 @default.
• W3176706054 cites W2005525629 @default.
• W3176706054 cites W2015957622 @default.
• W3176706054 cites W2019144360 @default.
• W3176706054 cites W2021315279 @default.
• W3176706054 cites W2021912535 @default.
• W3176706054 cites W2030472096 @default.
• W3176706054 cites W2032392617 @default.
• W3176706054 cites W2037262923 @default.
• W3176706054 cites W2049366603 @default.
• W3176706054 cites W2050786534 @default.
• W3176706054 cites W2053849251 @default.
• W3176706054 cites W2057115522 @default.
• W3176706054 cites W2061886862 @default.
• W3176706054 cites W2065048465 @default.
• W3176706054 cites W2070049573 @default.
• W3176706054 cites W2072500831 @default.
• W3176706054 cites W2075793841 @default.
• W3176706054 cites W2077044335 @default.
• W3176706054 cites W2089435862 @default.
• W3176706054 cites W2098382378 @default.
• W3176706054 cites W2103336276 @default.
• W3176706054 cites W2111216320 @default.
• W3176706054 cites W2111408945 @default.
• W3176706054 cites W2115298392 @default.
• W3176706054 cites W2123913108 @default.
• W3176706054 cites W2131222480 @default.
• W3176706054 cites W2141976392 @default.
• W3176706054 cites W2146180881 @default.
• W3176706054 cites W2148083750 @default.
• W3176706054 cites W2153429571 @default.
• W3176706054 cites W2156118851 @default.
• W3176706054 cites W2175637243 @default.
• W3176706054 cites W2215765427 @default.
• W3176706054 cites W2265150090 @default.
• W3176706054 cites W2474155883 @default.
• W3176706054 cites W2486618134 @default.
• W3176706054 cites W2599373832 @default.
• W3176706054 cites W2777403584 @default.
• W3176706054 cites W2780438715 @default.
• W3176706054 cites W2801538862 @default.
• W3176706054 cites W2884896164 @default.
• W3176706054 cites W2886227394 @default.
• W3176706054 cites W2901114324 @default.
• W3176706054 cites W2912264954 @default.
• W3176706054 cites W2912837809 @default.
• W3176706054 cites W2938590985 @default.
• W3176706054 cites W2970756712 @default.
• W3176706054 cites W2975170802 @default.
• W3176706054 cites W3092456180 @default.
• W3176706054 cites W4253518992 @default.
• W3176706054 cites W658341232 @default.
• W3176706054 doi "https://doi.org/10.1111/jnc.15461" @default.
• W3176706054 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34176164" @default.
• W3176706054 hasPublicationYear "2021" @default.
• W3176706054 type Work @default.
• W3176706054 sameAs 3176706054 @default.
• W3176706054 citedByCount "10" @default.
• W3176706054 countsByYear W31767060542021 @default.
• W3176706054 countsByYear W31767060542022 @default.
• W3176706054 countsByYear W31767060542023 @default.
• W3176706054 crossrefType "journal-article" @default.

• next