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- W317673831 abstract "This chapter focuses on the role of recessive genes, activated oncogenes, and chromosome abnormalities in the development of neuroectodermal cancers. Embryonic neuroectoderm gives rise to cells populating a number of adult tissues, including the central and peripheral nervous systems and retina. Among the tumors of neuroectodermal origin are medulloblastomas, meningiomas, and various glial tumors of the central nervous system, neuroblastomas and pheochromocytomas of the peripheral nervous system, and retinoblastomas of retina. Karyotypes have been prepared from multiple examples of each of these tumors. In virtually every instance, abnormalities of chromosome number (aneuploidy) and organization (structural rearrangements) have been demonstrated. The cytogenic and molecular genetic analysis of different neuroectodermal malignancies suggests that the aberrant expression of cellular oncogenes, either as an enhanced transcription of specific mRNAs or the production of altered proteins, plays a significant role in both the genesis and progression of cancer. The characterization of individual tumors, in terms of the particular activated oncogenes that each tumor contains, will almost certainly be of prognostic significance and could in future have therapeutic implications as well." @default.
- W317673831 created "2016-06-24" @default.
- W317673831 creator A5061280047 @default.
- W317673831 date "1988-01-01" @default.
- W317673831 modified "2023-09-28" @default.
- W317673831 title "Neuro-oncogenesis: recessive genes, activated oncogenes, and chromosome abnormalities in the development of neuroectodermal cancers" @default.
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- W317673831 doi "https://doi.org/10.1016/b978-0-407-02400-7.50014-7" @default.
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