FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3176752011> ?p ?o ?g. }

• W3176752011 endingPage "e0254018" @default.
• W3176752011 startingPage "e0254018" @default.
• W3176752011 abstract "Introduction In locally advanced rectal cancer, longer delay to surgery after neoadjuvant radiotherapy increases the likelihood of histopathological tumour response. Chronomodulated radiotherapy in rectal cancer has recently been reported as a factor increasing tumour response to neoadjuvant treatment in patients having earlier surgery, with patients receiving a larger proportion of afternoon treatments showing improved response. This paper aims to replicate this work by exploring the impact of these two temporal factors, independently and in combination, on histopathological tumour response in rectal cancer patients. Methods A retrospective review of all patients with rectal adenocarcinoma who received long course (≥24 fractions) neoadjuvant radiotherapy with or without chemotherapy at a tertiary referral centre was conducted. Delay to surgery and radiotherapy treatment time were correlated to clinicopathologic characteristics with a particular focus on tumour regression grade. A review of the literature and meta-analysis were also conducted to ascertain the impact of time to surgery from preoperative radiotherapy on tumour regression. Results From a cohort of 367 patients, 197 patients met the inclusion criteria. Complete pathologic response (AJCC regression grade 0) was seen in 46 (23%) patients with a further 44 patients (22%) having at most small groups of residual cells (AJCC regression grade 1). Median time to surgery was 63 days, and no statistically significant difference was seen in tumour regression between patients having early or late surgery. There was a non-significant trend towards a larger proportion of morning treatments in patients with grade 0 or 1 regression (p = 0.077). There was no difference in tumour regression when composite groups of the two temporal variables were analysed. Visualisation of data from 39 reviewed papers (describing 27379 patients) demonstrated a plateau of response to neoadjuvant radiotherapy after approximately 60 days, and a meta-analysis found improved complete pathologic response in patients having later surgery. Conclusions There was no observed benefit of chronomodulated radiotherapy in our cohort of rectal cancer patients. Review of the literature and meta-analysis confirms the benefit of delayed surgery, with a plateau in complete response rates at approximately 60-days between completion of radiotherapy and surgery. In our cohort, time to surgery for the majority of our patients lay along this plateau and this may be a more dominant factor in determining response to neoadjuvant therapy, obscuring any effects of chronomodulation on tumour response. We would recommend surgery be performed between 8 and 11 weeks after completion of neoadjuvant radiotherapy in patients with locally advanced rectal cancer." @default.
• W3176752011 created "2021-07-05" @default.
• W3176752011 creator A5000269245 @default.
• W3176752011 creator A5015405711 @default.
• W3176752011 creator A5020993306 @default.
• W3176752011 creator A5023529086 @default.
• W3176752011 creator A5075513432 @default.
• W3176752011 creator A5080500724 @default.
• W3176752011 date "2021-06-30" @default.
• W3176752011 modified "2023-09-26" @default.
• W3176752011 title "Temporal determinants of tumour response to neoadjuvant rectal radiotherapy" @default.
• W3176752011 cites W1826055758 @default.
• W3176752011 cites W1865957711 @default.
• W3176752011 cites W1892749772 @default.
• W3176752011 cites W1894792744 @default.
• W3176752011 cites W1896630734 @default.
• W3176752011 cites W1976176418 @default.
• W3176752011 cites W1977127004 @default.
• W3176752011 cites W1978546169 @default.
• W3176752011 cites W1979238043 @default.
• W3176752011 cites W1986872867 @default.
• W3176752011 cites W1994615279 @default.
• W3176752011 cites W1996167718 @default.
• W3176752011 cites W1997364930 @default.
• W3176752011 cites W2006856720 @default.
• W3176752011 cites W2014009122 @default.
• W3176752011 cites W2017233105 @default.
• W3176752011 cites W2020659765 @default.
• W3176752011 cites W2031866566 @default.
• W3176752011 cites W2036069859 @default.
• W3176752011 cites W2038068836 @default.
• W3176752011 cites W2039556095 @default.
• W3176752011 cites W2042552741 @default.
• W3176752011 cites W2050365174 @default.
• W3176752011 cites W2051685761 @default.
• W3176752011 cites W2051705756 @default.
• W3176752011 cites W2068898596 @default.
• W3176752011 cites W2089519715 @default.
• W3176752011 cites W2101719692 @default.
• W3176752011 cites W2108051921 @default.
• W3176752011 cites W2108148539 @default.
• W3176752011 cites W2113353705 @default.
• W3176752011 cites W2124914973 @default.
• W3176752011 cites W2127326400 @default.
• W3176752011 cites W2132565869 @default.
• W3176752011 cites W2138403078 @default.
• W3176752011 cites W2144717403 @default.
• W3176752011 cites W2147475401 @default.
• W3176752011 cites W2148308918 @default.
• W3176752011 cites W2159511785 @default.
• W3176752011 cites W2161523093 @default.
• W3176752011 cites W2162617501 @default.
• W3176752011 cites W2168201732 @default.
• W3176752011 cites W2274936953 @default.
• W3176752011 cites W2278681719 @default.
• W3176752011 cites W2332439395 @default.
• W3176752011 cites W2333025355 @default.
• W3176752011 cites W2492547438 @default.
• W3176752011 cites W2518860853 @default.
• W3176752011 cites W2519217614 @default.
• W3176752011 cites W2521490912 @default.
• W3176752011 cites W2521578090 @default.
• W3176752011 cites W2588955044 @default.
• W3176752011 cites W2599039136 @default.
• W3176752011 cites W2616515036 @default.
• W3176752011 cites W2889379497 @default.
• W3176752011 cites W2898705499 @default.
• W3176752011 cites W2899404326 @default.
• W3176752011 cites W2937253622 @default.
• W3176752011 cites W2943809003 @default.
• W3176752011 cites W2975424845 @default.
• W3176752011 cites W2979156429 @default.
• W3176752011 cites W4231241803 @default.
• W3176752011 doi "https://doi.org/10.1371/journal.pone.0254018" @default.
• W3176752011 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8244879" @default.
• W3176752011 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34191861" @default.
• W3176752011 hasPublicationYear "2021" @default.
• W3176752011 type Work @default.
• W3176752011 sameAs 3176752011 @default.
• W3176752011 citedByCount "0" @default.
• W3176752011 crossrefType "journal-article" @default.
• W3176752011 hasAuthorship W3176752011A5000269245 @default.
• W3176752011 hasAuthorship W3176752011A5015405711 @default.
• W3176752011 hasAuthorship W3176752011A5020993306 @default.
• W3176752011 hasAuthorship W3176752011A5023529086 @default.
• W3176752011 hasAuthorship W3176752011A5075513432 @default.
• W3176752011 hasAuthorship W3176752011A5080500724 @default.
• W3176752011 hasBestOaLocation W31767520111 @default.
• W3176752011 hasConcept C121608353 @default.
• W3176752011 hasConcept C126322002 @default.
• W3176752011 hasConcept C141071460 @default.
• W3176752011 hasConcept C143998085 @default.
• W3176752011 hasConcept C167135981 @default.
• W3176752011 hasConcept C2778292576 @default.
• W3176752011 hasConcept C509974204 @default.
• W3176752011 hasConcept C526805850 @default.
• W3176752011 hasConcept C530470458 @default.
• W3176752011 hasConcept C71924100 @default.

• next