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- W3176786260 abstract "Cruciferae vegetable contain high levels of chemopreventative glucosinolates. Spanish black radishes (SBR) are unique crucifers that contain 4X more glucosinolates than other crucifers, such as broccoli. This study examined whether feeding mice a diet containing 20 % Spanish black radish for two weeks prior to treatment with the carcinogen 7, 12-dimethylbenz(a)anthracene (DMBA) could enhance metabolism of this carcinogen and inhibit the DMBA-mediated bone marrow toxicity. Expression of Phase I and Phase II detoxification enzymes was significantly greater for mice on SBR diet. The blood levels of DMBA in SBR-fed mice were significantly lower than those on control diets. DMBA significantly reduced BM cells of mice fed control diet, whereas mice on the SBR diet showed diminished effect. Colony forming assays demonstrated that mice on the SBR diet had significantly: 1) less reduction in lymphoid CFU-preB progenitor cells, 2) greater recovery of CFU-preB progenitor cells, and 3) less reduction of CFU-GM progenitor cells. Therefore, mice fed a 20% SBR diet for two weeks had higher expression of detoxification enzymes, faster metabolism of DMBA and a reduction in DMBA-induced bone marrow toxicity." @default.
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- W3176786260 date "2012-04-01" @default.
- W3176786260 modified "2023-09-27" @default.
- W3176786260 title "Spanish Black Radish (Raphanus Sativus L. Var. niger) Diet Enhances Clearance of DMBA and Diminishes Toxic Effects on Bone Marrow Progenitor Cells" @default.
- W3176786260 doi "https://doi.org/10.1096/fasebj.26.1_supplement.1023.3" @default.
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