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- W3176870129 abstract "From Drosophila to mammals, the retina develops in a conserved wave-like pattern emanating from optic stalk to peripheral region. While Drosophila retinal differentiation is regulated by Hedgehog and Receptor Tyrosine Kinase (RTK) signaling in a sequential-induction fashion, whether such mechanism applies to vertebrate retinal development remains controversial. Previous studies have also implicated Fibroblast Growth Factor (FGF) signaling in specifying retina versus retinal pigmented epithelium (RPE) fate during early eye development, but the molecular mechanism of such profound effect of FGF signaling is still lacking. Shp2 protein tyrosine phosphatase is a critical mediator of many RTK pathways, including FGF signaling. We have determined the mechanism of FGF signaling in retinal development by studying the genetic ablation of Shp2, providing compelling genetic evidence that Shp2 is dispensable for the retinal differentiation wave or maintenance of retinal cell fate. In contrast, our results suggest that Shp2 signaling functions in early patterning of the optic vesicle." @default.
- W3176870129 created "2021-07-05" @default.
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- W3176870129 date "2009-04-01" @default.
- W3176870129 modified "2023-09-27" @default.
- W3176870129 title "Shp2 dependent FGF signaling in retinal development" @default.
- W3176870129 doi "https://doi.org/10.1096/fasebj.23.1_supplement.176.3" @default.
- W3176870129 hasPublicationYear "2009" @default.
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