Matches in SemOpenAlex for { <https://semopenalex.org/work/W3176882641> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W3176882641 abstract "Aldosterone (ALD) is a crucial hormone to regulate ENaC-mediated Na+ reabsorption in the kidney for controlling ECF volume and blood pressure. So far, we found ALD activated p38 and pretreatment with SB202190 (a specific p38 inhibitor: SB) abolished ALD-stimulated benzamil-sensitive Isc (INa ) by reducing benzamil-sensitive conductance (GNa). In this study, we investigated a physiological role of p38 in the surface expression of ENaC through exocytic and endocytic pathways in ALD-treated renal epithelial A6 cells by using MG132 (a proteasome inhibitor) and brefeldin A (an inhibitor of protein translocation). Pretreatment with MG132 mostly recovered the SB-induced reduction of INa, whreas brefeldin A showed further an inhibitory effect on the SB-decreased INa. Moreover, SB decreased both phosphorylated SGK1 and Nedd4-2. These suggest that the p38- mediated signal pathway suppresses the endocytic/proteasome-dependent ENaC degradation contributing to the stimulation of Na+ reabsorption by ALD. Supported by JSPS (19590212, 20390060), SSRF (0837, 1035) and FFPR." @default.
- W3176882641 created "2021-07-05" @default.
- W3176882641 creator A5056790528 @default.
- W3176882641 creator A5057965029 @default.
- W3176882641 date "2012-04-01" @default.
- W3176882641 modified "2023-10-16" @default.
- W3176882641 title "A physiological role of p38 on aldosterone‐dependent regulation of ENaC endocytosis in renal epithelial A6 cells" @default.
- W3176882641 doi "https://doi.org/10.1096/fasebj.26.1_supplement.867.14" @default.
- W3176882641 hasPublicationYear "2012" @default.
- W3176882641 type Work @default.
- W3176882641 sameAs 3176882641 @default.
- W3176882641 citedByCount "0" @default.
- W3176882641 crossrefType "journal-article" @default.
- W3176882641 hasAuthorship W3176882641A5056790528 @default.
- W3176882641 hasAuthorship W3176882641A5057965029 @default.
- W3176882641 hasConcept C104317684 @default.
- W3176882641 hasConcept C119062480 @default.
- W3176882641 hasConcept C11960822 @default.
- W3176882641 hasConcept C126322002 @default.
- W3176882641 hasConcept C134018914 @default.
- W3176882641 hasConcept C134459356 @default.
- W3176882641 hasConcept C1491633281 @default.
- W3176882641 hasConcept C158617107 @default.
- W3176882641 hasConcept C178790620 @default.
- W3176882641 hasConcept C184150571 @default.
- W3176882641 hasConcept C185592680 @default.
- W3176882641 hasConcept C25602115 @default.
- W3176882641 hasConcept C27740335 @default.
- W3176882641 hasConcept C2777265272 @default.
- W3176882641 hasConcept C2778212192 @default.
- W3176882641 hasConcept C2778367456 @default.
- W3176882641 hasConcept C2778506107 @default.
- W3176882641 hasConcept C2778525890 @default.
- W3176882641 hasConcept C2780091579 @default.
- W3176882641 hasConcept C2781373781 @default.
- W3176882641 hasConcept C28005876 @default.
- W3176882641 hasConcept C41625074 @default.
- W3176882641 hasConcept C537181965 @default.
- W3176882641 hasConcept C55493867 @default.
- W3176882641 hasConcept C56906281 @default.
- W3176882641 hasConcept C6507245 @default.
- W3176882641 hasConcept C71924100 @default.
- W3176882641 hasConcept C79747257 @default.
- W3176882641 hasConcept C86803240 @default.
- W3176882641 hasConcept C95444343 @default.
- W3176882641 hasConcept C99975950 @default.
- W3176882641 hasConceptScore W3176882641C104317684 @default.
- W3176882641 hasConceptScore W3176882641C119062480 @default.
- W3176882641 hasConceptScore W3176882641C11960822 @default.
- W3176882641 hasConceptScore W3176882641C126322002 @default.
- W3176882641 hasConceptScore W3176882641C134018914 @default.
- W3176882641 hasConceptScore W3176882641C134459356 @default.
- W3176882641 hasConceptScore W3176882641C1491633281 @default.
- W3176882641 hasConceptScore W3176882641C158617107 @default.
- W3176882641 hasConceptScore W3176882641C178790620 @default.
- W3176882641 hasConceptScore W3176882641C184150571 @default.
- W3176882641 hasConceptScore W3176882641C185592680 @default.
- W3176882641 hasConceptScore W3176882641C25602115 @default.
- W3176882641 hasConceptScore W3176882641C27740335 @default.
- W3176882641 hasConceptScore W3176882641C2777265272 @default.
- W3176882641 hasConceptScore W3176882641C2778212192 @default.
- W3176882641 hasConceptScore W3176882641C2778367456 @default.
- W3176882641 hasConceptScore W3176882641C2778506107 @default.
- W3176882641 hasConceptScore W3176882641C2778525890 @default.
- W3176882641 hasConceptScore W3176882641C2780091579 @default.
- W3176882641 hasConceptScore W3176882641C2781373781 @default.
- W3176882641 hasConceptScore W3176882641C28005876 @default.
- W3176882641 hasConceptScore W3176882641C41625074 @default.
- W3176882641 hasConceptScore W3176882641C537181965 @default.
- W3176882641 hasConceptScore W3176882641C55493867 @default.
- W3176882641 hasConceptScore W3176882641C56906281 @default.
- W3176882641 hasConceptScore W3176882641C6507245 @default.
- W3176882641 hasConceptScore W3176882641C71924100 @default.
- W3176882641 hasConceptScore W3176882641C79747257 @default.
- W3176882641 hasConceptScore W3176882641C86803240 @default.
- W3176882641 hasConceptScore W3176882641C95444343 @default.
- W3176882641 hasConceptScore W3176882641C99975950 @default.
- W3176882641 hasFunder F4320311436 @default.
- W3176882641 hasFunder F4320334764 @default.
- W3176882641 hasIssue "S1" @default.
- W3176882641 hasLocation W31768826411 @default.
- W3176882641 hasOpenAccess W3176882641 @default.
- W3176882641 hasPrimaryLocation W31768826411 @default.
- W3176882641 hasRelatedWork W186715032 @default.
- W3176882641 hasRelatedWork W1970149009 @default.
- W3176882641 hasRelatedWork W1979244538 @default.
- W3176882641 hasRelatedWork W2039855082 @default.
- W3176882641 hasRelatedWork W2044290440 @default.
- W3176882641 hasRelatedWork W2122221794 @default.
- W3176882641 hasRelatedWork W2162791063 @default.
- W3176882641 hasRelatedWork W2342803240 @default.
- W3176882641 hasRelatedWork W2751430556 @default.
- W3176882641 hasRelatedWork W3176882641 @default.
- W3176882641 hasVolume "26" @default.
- W3176882641 isParatext "false" @default.
- W3176882641 isRetracted "false" @default.
- W3176882641 magId "3176882641" @default.
- W3176882641 workType "article" @default.