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- W3176941859 abstract "Modulation of mitochondrial biogenesis (MB) has been proposed to play a potentially critical role in the cardiac response to ischemia-reperfusion (I/R), however, the specific effect of IR on MB has been little studied. We previously observed a significant increase in apparent cardiac mitochondrial mass after I/R in mice. Here we examined whether I/R-induced increases in mitochondrial mass were associated with changes in mitochondrial respiratory activity. Mice were subjected to 30 occlusion of the left anterior descending coronary artery followed by 4 h reperfusion. Hearts were harvested for determination of both mitochondrial and nuclear DNA (mtDNA, nDNA, respectively) and measurement of respiratory activity in isolated mitochondria. The ratio of mtDNA/nDNA was increased 2–4-fold by I/R. This was associated with significant decreases in both glutamate/malate- and succinate-fueled oxygen consumption , as well as decreased respiratory control ratio (state3/state4). These results suggest that acute increases in mitochondrial biogenesis may be a compensatory but maladaptive response to I/R-induced mitochondrial dysfunction, analogous to chronic mitochondrial cardiomyopathies. Supported by NIH AA-014945 and HL-095486." @default.
- W3176941859 created "2021-07-05" @default.
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- W3176941859 date "2013-04-01" @default.
- W3176941859 modified "2023-10-07" @default.
- W3176941859 title "Cardiac ischemia reperfusion elicits increased mitochondrial mass but decreased mitochondrial respiration in mice" @default.
- W3176941859 doi "https://doi.org/10.1096/fasebj.27.1_supplement.682.7" @default.
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