FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3176973925> ?p ?o ?g. }

• W3176973925 abstract "Knowledge about in vivo effects of human circulating C-6 hydroxylated bile acids (BAs), also called muricholic acids, is sparse. It is unsettled if the gut microbiome might contribute to their biosynthesis. Here, we measured a range of serum BAs and related them to markers of human metabolic health and the gut microbiome. We examined 283 non-obese and obese Danish adults from the MetaHit study. Fasting concentrations of serum BAs were quantified using ultra-performance liquid chromatography-tandem mass-spectrometry. The gut microbiome was characterized with shotgun metagenomic sequencing and genome-scale metabolic modeling. We find that tauro- and glycohyocholic acid correlated inversely with body mass index (P = 4.1e-03, P = 1.9e-05, respectively), waist circumference (P = 0.017, P = 1.1e-04, respectively), body fat percentage (P = 2.5e-03, P = 2.3e-06, respectively), insulin resistance (P = 0.051, P = 4.6e-4, respectively), fasting concentrations of triglycerides (P = 0.06, P = 9.2e-4, respectively) and leptin (P = 0.067, P = 9.2e-4). Tauro- and glycohyocholic acids, and tauro-a-muricholic acid were directly linked with a distinct gut microbial community primarily composed of Clostridia species (P = 0.037, P = 0.013, P = 0.027, respectively). We conclude that serum conjugated C-6-hydroxylated BAs associate with measures of human metabolic health and gut communities of Clostridia species. The findings merit preclinical interventions and human feasibility studies to explore the therapeutic potential of these BAs in obesity and type 2 diabetes." @default.
• W3176973925 created "2021-07-05" @default.
• W3176973925 creator A5005786132 @default.
• W3176973925 creator A5008523423 @default.
• W3176973925 creator A5015351528 @default.
• W3176973925 creator A5026900535 @default.
• W3176973925 creator A5036338209 @default.
• W3176973925 creator A5037198878 @default.
• W3176973925 creator A5038554825 @default.
• W3176973925 creator A5050914910 @default.
• W3176973925 creator A5057545483 @default.
• W3176973925 creator A5058408778 @default.
• W3176973925 creator A5066665434 @default.
• W3176973925 creator A5068801040 @default.
• W3176973925 creator A5069282408 @default.
• W3176973925 creator A5083895460 @default.
• W3176973925 creator A5085186689 @default.
• W3176973925 creator A5085970754 @default.
• W3176973925 date "2021-06-24" @default.
• W3176973925 modified "2023-10-03" @default.
• W3176973925 title "Conjugated C-6 hydroxylated bile acids in serum relate to human metabolic health and gut Clostridia species" @default.
• W3176973925 cites W1860088671 @default.
• W3176973925 cites W1963587340 @default.
• W3176973925 cites W1982889435 @default.
• W3176973925 cites W2001561488 @default.
• W3176973925 cites W2004320689 @default.
• W3176973925 cites W2004549986 @default.
• W3176973925 cites W2022279737 @default.
• W3176973925 cites W2049169935 @default.
• W3176973925 cites W2051619918 @default.
• W3176973925 cites W2071273298 @default.
• W3176973925 cites W2078810890 @default.
• W3176973925 cites W2081028309 @default.
• W3176973925 cites W2096155567 @default.
• W3176973925 cites W2096173332 @default.
• W3176973925 cites W2097124003 @default.
• W3176973925 cites W2102459969 @default.
• W3176973925 cites W2106515170 @default.
• W3176973925 cites W2167062509 @default.
• W3176973925 cites W2326819017 @default.
• W3176973925 cites W2428595929 @default.
• W3176973925 cites W2559597060 @default.
• W3176973925 cites W2625485505 @default.
• W3176973925 cites W2744749251 @default.
• W3176973925 cites W2784331257 @default.
• W3176973925 cites W2789128799 @default.
• W3176973925 cites W2808494948 @default.
• W3176973925 cites W2989773357 @default.
• W3176973925 cites W3045598360 @default.
• W3176973925 doi "https://doi.org/10.1038/s41598-021-91482-y" @default.
• W3176973925 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8225906" @default.
• W3176973925 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34168163" @default.
• W3176973925 hasPublicationYear "2021" @default.
• W3176973925 type Work @default.
• W3176973925 sameAs 3176973925 @default.
• W3176973925 citedByCount "6" @default.
• W3176973925 countsByYear W31769739252021 @default.
• W3176973925 countsByYear W31769739252022 @default.
• W3176973925 countsByYear W31769739252023 @default.
• W3176973925 crossrefType "journal-article" @default.
• W3176973925 hasAuthorship W3176973925A5005786132 @default.
• W3176973925 hasAuthorship W3176973925A5008523423 @default.
• W3176973925 hasAuthorship W3176973925A5015351528 @default.
• W3176973925 hasAuthorship W3176973925A5026900535 @default.
• W3176973925 hasAuthorship W3176973925A5036338209 @default.
• W3176973925 hasAuthorship W3176973925A5037198878 @default.
• W3176973925 hasAuthorship W3176973925A5038554825 @default.
• W3176973925 hasAuthorship W3176973925A5050914910 @default.
• W3176973925 hasAuthorship W3176973925A5057545483 @default.
• W3176973925 hasAuthorship W3176973925A5058408778 @default.
• W3176973925 hasAuthorship W3176973925A5066665434 @default.
• W3176973925 hasAuthorship W3176973925A5068801040 @default.
• W3176973925 hasAuthorship W3176973925A5069282408 @default.
• W3176973925 hasAuthorship W3176973925A5083895460 @default.
• W3176973925 hasAuthorship W3176973925A5085186689 @default.
• W3176973925 hasAuthorship W3176973925A5085970754 @default.
• W3176973925 hasBestOaLocation W31769739251 @default.
• W3176973925 hasConcept C104317684 @default.
• W3176973925 hasConcept C126322002 @default.
• W3176973925 hasConcept C134018914 @default.
• W3176973925 hasConcept C143121216 @default.
• W3176973925 hasConcept C15151743 @default.
• W3176973925 hasConcept C2778312467 @default.
• W3176973925 hasConcept C2779399885 @default.
• W3176973925 hasConcept C2780480987 @default.
• W3176973925 hasConcept C511355011 @default.
• W3176973925 hasConcept C523546767 @default.
• W3176973925 hasConcept C539455810 @default.
• W3176973925 hasConcept C54355233 @default.
• W3176973925 hasConcept C55493867 @default.
• W3176973925 hasConcept C60644358 @default.
• W3176973925 hasConcept C71924100 @default.
• W3176973925 hasConcept C86803240 @default.
• W3176973925 hasConceptScore W3176973925C104317684 @default.
• W3176973925 hasConceptScore W3176973925C126322002 @default.
• W3176973925 hasConceptScore W3176973925C134018914 @default.
• W3176973925 hasConceptScore W3176973925C143121216 @default.
• W3176973925 hasConceptScore W3176973925C15151743 @default.
• W3176973925 hasConceptScore W3176973925C2778312467 @default.
• W3176973925 hasConceptScore W3176973925C2779399885 @default.

• next