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- W3176996444 abstract "Although precise evidence is missing, lung is believed to be a target of remote injury. We addressed this issue as well as any anti-inflammatory effects of lidocaine in an equine model of intestinal ischemia-reperfusion (IR). Lungs were collected from non-anesthetized (n=4) and anesthetized (n=4) control horses and those subjected to IR with administration of either Lactated Ringer's Solution (LRS) or lidocaine (n=6/group). Lungs from control groups had normal histology and lacked inflammation compared to moderate to severe congestion and vascular, perivascular and alveolar neutrophil recruitment in IR horses. Lungs from IR horses had increased TLR4 and TLR9 staining in terminal bronchioles and vascular cells, increased vWF staining and vWF-positive platelet aggregates in vasculature. IR horses had increase in Mac387-positive leukocytes and TNFα lung concentrations compared to control (P<0.05). Macrophage numbers were higher in IR horses receiving lidocaine compared to the LRS group (P<0.05). Neutrophil numbers were higher in LRS-treated IR horses compared to those administered lidocaine (P<0.05). MPO concentration was not different between IR groups. These data show IR-associated remote lung inflammation and injury in horses, and some amelioration of lung inflammation with lidocaine." @default.
- W3176996444 created "2021-07-05" @default.
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- W3176996444 date "2013-04-01" @default.
- W3176996444 modified "2023-09-23" @default.
- W3176996444 title "Remote lung injury after experimental intestinal ischemia‐reperfusion in horses" @default.
- W3176996444 doi "https://doi.org/10.1096/fasebj.27.1_supplement.254.7" @default.
- W3176996444 hasPublicationYear "2013" @default.
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