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- W3177014770 abstract "AIM: elucidate changes involved in nitrosative stress using an ovine model of ALI. METHOD: Sheep (n=5 per group) were surgically instrumented for chronic study. 5 days after surgery, the animals were randomly allocated as follows: Injury (instrumented; 3rd degree 40% total body surface area flame burn and insufflation with 48 breaths of cotton smoke under deep anesthesia) and sacrificed at the following time points post-injury: T=4hr, 8hr, 12hr, and 24hr; control (instrumented; no injury). Data is reported as mean ± SEM. RESULTS: Pulmonary gas exchange decreased 24h post burn and smoke injury (p < 0.05) and correlated with increased lung water content at 18h and 24 h (p< 0.05). Inducible nitric oxide synthase (iNOS) expression increased after injury compared with the control groups; peak iNOS expression was at 12h post burn and smoke inhalation (p < 0.05 vs control). Plasma nitrate/nitrite (NOx) correlated with protein expression: plasma NOx values increased 12h post injury (p = 0.046). 3-nitrotyrosine (index of reactive nitrogen species) increased after burn and smoke inhalation compared to control (p < 0.05, n=5). DNA damage was assessed by measuring repair enzyme, poly (ADP) ribose polymerase (PARP) which increased in the injury group (p < 0.05 vs control). CONCLUSION: Therapeutic interventions to mediate excess free radical production could ameliorate impaired pulmonary function associated with ALI." @default.
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- W3177014770 date "2008-03-01" @default.
- W3177014770 modified "2023-10-18" @default.
- W3177014770 title "Nitrosative Stress in an Ovine Model of Acute Lung Injury" @default.
- W3177014770 doi "https://doi.org/10.1096/fasebj.22.1_supplement.1227.14" @default.
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