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- W3177015417 abstract "Breast cancer (BC) is the one of crucial health burden among women worldwide. Even though the alteration of vascular function were observed by few researchers in metastatic BC, the changes in vascular reactivity and its underlying mechanism were not fully understood. Here, we investigate the physiological changes of vascular function from isolated mesenteric arteries in metastatic breast cancer mice model. In this study, 105 of 4T1 murine BC cells were injected into the subcutaneous or tail vein of female Balb-c mice aged 8 weeks old. Mice were randomly divided into the following group: 1) control; n=10, 2) non-metastatic model (4T1; n=10), 3) tumor-bearing model (4T1M; n=10), and 4) tail vein injection model (4T1ML; n=10). Mesenteric arteries were removed after 4 weeks of tail vein injection group and 5 weeks of tumor-bearing groups. Isometric tension was investigated in response to various vasoconstrictors such as phenylephrine (PhE), Serotonin (5-HT), Angiotensin II (ANG II) and high potassium chloride (HK). Our results showed that PhE-induced vasoconstriction was no significant differences in the non-metastatic group compared to control. However, the attenuated vasoconstriction in response to PhE, 5-HT, and High K was found in metastatic cancer groups. Application of L-type voltage-gated calcium channel inhibitor (Nifedipine) induced vascular relaxation with PhE-induced contraction in each group, but there were no significant differences among groups. Interestingly, PhE-induced contraction in metastatic groups was not inhibited by Rho kinase inhibitor (Y-27632), but not in control. From above results, it is suggested that decreased Rho kinase activity might be attributable to attenuated vasoconstriction in mesenteric artery from advanced breast cancer mice. Support or Funding Information This study was supported by a National Research Foundation of Korea grant funded by Ministry of Science, ICT, & Future Planning (2015R1C1A1A01054038). This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal." @default.
- W3177015417 created "2021-07-05" @default.
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- W3177015417 date "2018-04-01" @default.
- W3177015417 modified "2023-09-23" @default.
- W3177015417 title "Attenuation of Vascular Contractility in Metastatic Breast Cancer Mice" @default.
- W3177015417 doi "https://doi.org/10.1096/fasebj.2018.32.1_supplement.770.1" @default.
- W3177015417 hasPublicationYear "2018" @default.
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