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- W3177044774 endingPage "798" @default.
- W3177044774 startingPage "787" @default.
- W3177044774 abstract "The major medical advances in our knowledge of the human leukocyte antigen (HLA) system have allowed us to uncover several gaps in our understanding of alloimmunity. Although the non-HLA system has long sparked the interest of the transplant community, recognition of the role of immunity to non-HLA antigenic targets has only emerged recently. In this review, we will provide a comprehensive summary of the paradigm-changing concept of immunity to the non-HLA angiotensin II type 1 receptor (AT1R), discovered by Duška Dragun et al., that began from careful bedside clinical observations, to validated detection of anti-AT1R antibodies and lead to clinical intervention. This scientific approach has also allowed the recognition of broader pathogenicity of anti-AT1R antibodies across multiple organ transplants and in other human diseases, the integration of both non-HLA and HLA systems to understand their immunologic effects on organ allografts, and the identification of future directions for therapeutic intervention to modulate immunity to AT1R. Rationally designed successful interventions to target AT1R system provide an exemplar for other non-HLA antibodies to cross borders between medical specialties, will generate new avenues in translational research beyond transplantation, and will foster the development of new and reliable tools to improve our understanding of non-HLA immunity and ultimately allow us to improve patient care." @default.
- W3177044774 created "2021-07-05" @default.
- W3177044774 creator A5006946051 @default.
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- W3177044774 creator A5055171681 @default.
- W3177044774 creator A5061736643 @default.
- W3177044774 creator A5091069264 @default.
- W3177044774 date "2021-10-01" @default.
- W3177044774 modified "2023-09-30" @default.
- W3177044774 title "The emerging field of non–human leukocyte antigen antibodies in transplant medicine and beyond" @default.
- W3177044774 cites W1550905784 @default.
- W3177044774 cites W1579462871 @default.
- W3177044774 cites W1820273416 @default.
- W3177044774 cites W1948702528 @default.
- W3177044774 cites W1963746385 @default.
- W3177044774 cites W1964673612 @default.
- W3177044774 cites W1965367261 @default.
- W3177044774 cites W1970613671 @default.
- W3177044774 cites W1971221182 @default.
- W3177044774 cites W1982401463 @default.
- W3177044774 cites W1989968456 @default.
- W3177044774 cites W1992563074 @default.
- W3177044774 cites W1995972557 @default.
- W3177044774 cites W1998760435 @default.
- W3177044774 cites W2001455084 @default.
- W3177044774 cites W2003276740 @default.
- W3177044774 cites W2011178910 @default.
- W3177044774 cites W2013313329 @default.
- W3177044774 cites W2016453383 @default.
- W3177044774 cites W2018624539 @default.
- W3177044774 cites W2022267253 @default.
- W3177044774 cites W2023195146 @default.
- W3177044774 cites W2023453199 @default.
- W3177044774 cites W2033614711 @default.
- W3177044774 cites W2034460009 @default.
- W3177044774 cites W2041517672 @default.
- W3177044774 cites W2042294166 @default.
- W3177044774 cites W2047292563 @default.
- W3177044774 cites W2051872988 @default.
- W3177044774 cites W2053112518 @default.
- W3177044774 cites W2055815452 @default.
- W3177044774 cites W2064143839 @default.
- W3177044774 cites W2072126804 @default.
- W3177044774 cites W2074747030 @default.
- W3177044774 cites W2076789595 @default.
- W3177044774 cites W2076927183 @default.
- W3177044774 cites W2077069780 @default.
- W3177044774 cites W2081617461 @default.
- W3177044774 cites W2086484480 @default.
- W3177044774 cites W2088133172 @default.
- W3177044774 cites W2089221056 @default.
- W3177044774 cites W2097115382 @default.
- W3177044774 cites W2097293181 @default.
- W3177044774 cites W2098824799 @default.
- W3177044774 cites W2099850315 @default.
- W3177044774 cites W2103900274 @default.
- W3177044774 cites W2110177837 @default.
- W3177044774 cites W2111227601 @default.
- W3177044774 cites W2112087941 @default.
- W3177044774 cites W2112446334 @default.
- W3177044774 cites W2113519753 @default.
- W3177044774 cites W2113590606 @default.
- W3177044774 cites W2115165922 @default.
- W3177044774 cites W2115660072 @default.
- W3177044774 cites W2121137478 @default.
- W3177044774 cites W2129459717 @default.
- W3177044774 cites W2130264854 @default.
- W3177044774 cites W2130820062 @default.
- W3177044774 cites W2132634496 @default.
- W3177044774 cites W2136474992 @default.
- W3177044774 cites W2136639485 @default.
- W3177044774 cites W2136840699 @default.
- W3177044774 cites W2140785684 @default.
- W3177044774 cites W2143265118 @default.
- W3177044774 cites W2143764193 @default.
- W3177044774 cites W2157046471 @default.
- W3177044774 cites W2160705469 @default.
- W3177044774 cites W2162381208 @default.
- W3177044774 cites W2166071580 @default.
- W3177044774 cites W2168882952 @default.
- W3177044774 cites W2169605955 @default.
- W3177044774 cites W2169919872 @default.
- W3177044774 cites W2172432588 @default.
- W3177044774 cites W2179348585 @default.
- W3177044774 cites W2204472766 @default.
- W3177044774 cites W2330179935 @default.
- W3177044774 cites W2350628112 @default.
- W3177044774 cites W2418954789 @default.
- W3177044774 cites W2460046174 @default.
- W3177044774 cites W2461100821 @default.
- W3177044774 cites W2509342076 @default.
- W3177044774 cites W2510101709 @default.
- W3177044774 cites W2513273349 @default.
- W3177044774 cites W2534575158 @default.
- W3177044774 cites W2536412454 @default.
- W3177044774 cites W2552263672 @default.
- W3177044774 cites W2585608783 @default.
- W3177044774 cites W2619900942 @default.