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• W3177093973 startingPage "21" @default.
• W3177093973 abstract "Cardiovascular diseases are a common cause of death worldwide. Adult cardiomyocytes have limited regenerative capacity after injury, and there is growing interest in cardiac regeneration as a new therapeutic strategy. There are several limitations of induced pluripotent stem cell-based transplantation therapy with respect to efficiency and risks of tumorigenesis. Direct reprogramming enables the conversion of terminally differentiated cells into target cell types using defined factors. In most cardiac diseases, activated fibroblasts proliferate in the damaged heart and contribute to the progression of heart failure. In vivo cardiac reprogramming, in which resident cardiac fibroblasts are converted into cardiomyocytes in situ, is expected to become a new cardiac regenerative therapy. Indeed, we and other groups have demonstrated that in vivo reprogramming improves cardiac function and reduces fibrosis after myocardial infarction. In this review, we summarize recent discoveries and developments related to in vivo reprogramming. In addition, issues that need to be resolved for clinical application are described." @default.
• W3177093973 created "2021-07-05" @default.
• W3177093973 creator A5011276506 @default.
• W3177093973 creator A5083622539 @default.
• W3177093973 date "2022-02-01" @default.
• W3177093973 modified "2023-10-14" @default.
• W3177093973 title "In vivo reprogramming as a new approach to cardiac regenerative therapy" @default.
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• W3177093973 doi "https://doi.org/10.1016/j.semcdb.2021.06.019" @default.
• W3177093973 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34210577" @default.
• W3177093973 hasPublicationYear "2022" @default.
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