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• W3177130789 endingPage "577649" @default.
• W3177130789 startingPage "577649" @default.
• W3177130789 abstract "HIV-1 is responsible for the development of a spectrum of cognitive impairments known as HIV-associated neurocognitive disorder (HAND). In the era of antiretroviral therapy (ART), HAND remains prevalent in people living with HIV (PLWH), despite low or undetectable viral loads. Persistent neuroinflammation likely plays an important role in the contributing biological mechanisms. Multiple cerebrospinal fluid (CSF) immune markers have been studied but it is unclear which markers most consistently correlate with neurocognitive impairment. We therefore conducted a systematic review of studies of the association of CSF immune markers with neurocognitive performance in ART-experienced PLWH. We aimed to synthesize the published data to determine consistent findings and to indicate the most noteworthy CSF markers of HAND. Twenty-nine studies were included, with 20 cross-sectional studies and 9 longitudinal studies. From the group of markers most often assayed, specific monocyte activation (higher levels of Neopterin, sCD163, sCD14) and neuroinflammatory markers (higher levels of IFN-γ, IL-1α, IL-7, IL-8, sTNFR-II and lower levels of IL-6) showed a consistent direction in association with HIV-associated neurocognitive impairment. Furthermore, significant differences exist in CSF immune markers between HIV-positive people with and without neurocognitive impairment, regardless of viral load and nadir/current CD4+ count. These markers may be useful in furthering our understanding of the neuropathology, diagnosis and prognosis of HAND. Studies using prospective designs (i.e. pre- and post-interventions), multi-modal methods (e.g. imaging, inflammation and neurocognitive evaluations) and utilizing a combination of the markers most commonly associated with HAND may help delineate the mechanisms of HAND." @default.
• W3177130789 created "2021-07-05" @default.
• W3177130789 creator A5048050790 @default.
• W3177130789 creator A5070358573 @default.
• W3177130789 creator A5073216705 @default.
• W3177130789 creator A5086562398 @default.
• W3177130789 date "2021-09-01" @default.
• W3177130789 modified "2023-10-14" @default.
• W3177130789 title "Cerebrospinal fluid immune markers and HIV-associated neurocognitive impairments: A systematic review" @default.
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• W3177130789 doi "https://doi.org/10.1016/j.jneuroim.2021.577649" @default.
• W3177130789 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34280844" @default.
• W3177130789 hasPublicationYear "2021" @default.
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