FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3177139264> ?p ?o ?g. }

• W3177139264 endingPage "2953" @default.
• W3177139264 startingPage "2941" @default.
• W3177139264 abstract "Inflammatory bowel diseases (IBD) are a chronic inflammatory disease, which affects almost all tissues in the body. Previous studies mainly focused on breathing, fecal, and urine samples of patients with IBD. However, there is no comprehensive metabolomic analysis of the serum, colon, heart, liver, kidney, cortex, hippocampus, and brown fat tissues. Therefore, the aim of our study is to evaluate the utility metabolomic analysis of target tissues in the pathogenesis of IBD in exploring new biomarkers for early diagnosis and treatment.Male Sprague-Dawley rats were randomly allocated to control and DSS-treated groups (n = 7). Dextran sulfate sodium (DSS) was orally administered for 6 weeks. Gas chromatography-mass spectrometry (GC-MS) was used for metabolite determination, multivariate statistical analysis was used to identify metabolites that were differentially expressed in two groups.Our results showed that 3, 11, 12, 6, 5, 13, 13, and 11 metabolites were differentially expressed between the DSS treatment group and the control group in the serum, colon, heart, liver, kidney, cortex, hippocampus, and brown fat tissues, respectively. The most significant change of metabolites in the study was amino acid (L-alanine, L-glutamic acid, L-phenylalanine, L-proline, L-lysine, L-isoleucine, L-tryptophan, L-norleucine, L-valine, glycine, serine, L-threonine), organic acid (citric acid, 3-hydroxybutyric acid, propanoic acid), glucide (D-arabinose, D-fructose) and purine (9H-purin-6-ol, D-ribose) profiles. Several pathways were affected according to the integrated pathway analysis. These pathways ranged from amino acid metabolism (such as alanine, aspartate, and glutamate metabolism, glutathione metabolism) to purine metabolism (aminoacyl-tRNA biosynthesis).Using GC-MS-based profiling of metabolite changes, these results may provide a more comprehensive view for IBD and IBD-related diseases and improve the understanding of IBD pathogenesis." @default.
• W3177139264 created "2021-07-05" @default.
• W3177139264 creator A5004718466 @default.
• W3177139264 creator A5019925485 @default.
• W3177139264 creator A5024189982 @default.
• W3177139264 creator A5031372199 @default.
• W3177139264 creator A5032682915 @default.
• W3177139264 creator A5034511104 @default.
• W3177139264 creator A5038594520 @default.
• W3177139264 creator A5044419532 @default.
• W3177139264 creator A5055145179 @default.
• W3177139264 creator A5074254927 @default.
• W3177139264 date "2021-07-01" @default.
• W3177139264 modified "2023-10-15" @default.
• W3177139264 title "Systematic Metabolic Profiling of Mice with Dextran Sulfate Sodium-Induced Colitis" @default.
• W3177139264 cites W1546655977 @default.
• W3177139264 cites W1630881925 @default.
• W3177139264 cites W1736417332 @default.
• W3177139264 cites W190437155 @default.
• W3177139264 cites W1965152505 @default.
• W3177139264 cites W1966010545 @default.
• W3177139264 cites W1992699090 @default.
• W3177139264 cites W2001788451 @default.
• W3177139264 cites W2005356765 @default.
• W3177139264 cites W2039687911 @default.
• W3177139264 cites W2051692635 @default.
• W3177139264 cites W2110758916 @default.
• W3177139264 cites W2144215119 @default.
• W3177139264 cites W2144750725 @default.
• W3177139264 cites W2149907341 @default.
• W3177139264 cites W2168024298 @default.
• W3177139264 cites W2180305266 @default.
• W3177139264 cites W2192147642 @default.
• W3177139264 cites W2333625724 @default.
• W3177139264 cites W2343482357 @default.
• W3177139264 cites W2556597560 @default.
• W3177139264 cites W2606152360 @default.
• W3177139264 cites W2771367031 @default.
• W3177139264 cites W2772755298 @default.
• W3177139264 cites W2790141134 @default.
• W3177139264 cites W2804157958 @default.
• W3177139264 cites W2914547283 @default.
• W3177139264 cites W2914783967 @default.
• W3177139264 cites W2972732614 @default.
• W3177139264 cites W2983565404 @default.
• W3177139264 cites W3081330689 @default.
• W3177139264 cites W4211241312 @default.
• W3177139264 cites W4244626580 @default.
• W3177139264 doi "https://doi.org/10.2147/jir.s313374" @default.
• W3177139264 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8259941" @default.
• W3177139264 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34239317" @default.
• W3177139264 hasPublicationYear "2021" @default.
• W3177139264 type Work @default.
• W3177139264 sameAs 3177139264 @default.
• W3177139264 citedByCount "16" @default.
• W3177139264 countsByYear W31771392642022 @default.
• W3177139264 countsByYear W31771392642023 @default.
• W3177139264 crossrefType "journal-article" @default.
• W3177139264 hasAuthorship W3177139264A5004718466 @default.
• W3177139264 hasAuthorship W3177139264A5019925485 @default.
• W3177139264 hasAuthorship W3177139264A5024189982 @default.
• W3177139264 hasAuthorship W3177139264A5031372199 @default.
• W3177139264 hasAuthorship W3177139264A5032682915 @default.
• W3177139264 hasAuthorship W3177139264A5034511104 @default.
• W3177139264 hasAuthorship W3177139264A5038594520 @default.
• W3177139264 hasAuthorship W3177139264A5044419532 @default.
• W3177139264 hasAuthorship W3177139264A5055145179 @default.
• W3177139264 hasAuthorship W3177139264A5074254927 @default.
• W3177139264 hasBestOaLocation W31771392641 @default.
• W3177139264 hasConcept C126322002 @default.
• W3177139264 hasConcept C134018914 @default.
• W3177139264 hasConcept C185592680 @default.
• W3177139264 hasConcept C2776580952 @default.
• W3177139264 hasConcept C2776991927 @default.
• W3177139264 hasConcept C2777305461 @default.
• W3177139264 hasConcept C2777477808 @default.
• W3177139264 hasConcept C2777573094 @default.
• W3177139264 hasConcept C2779349466 @default.
• W3177139264 hasConcept C515207424 @default.
• W3177139264 hasConcept C55493867 @default.
• W3177139264 hasConcept C62231903 @default.
• W3177139264 hasConcept C71924100 @default.
• W3177139264 hasConcept C86803240 @default.
• W3177139264 hasConcept C98274493 @default.
• W3177139264 hasConceptScore W3177139264C126322002 @default.
• W3177139264 hasConceptScore W3177139264C134018914 @default.
• W3177139264 hasConceptScore W3177139264C185592680 @default.
• W3177139264 hasConceptScore W3177139264C2776580952 @default.
• W3177139264 hasConceptScore W3177139264C2776991927 @default.
• W3177139264 hasConceptScore W3177139264C2777305461 @default.
• W3177139264 hasConceptScore W3177139264C2777477808 @default.
• W3177139264 hasConceptScore W3177139264C2777573094 @default.
• W3177139264 hasConceptScore W3177139264C2779349466 @default.
• W3177139264 hasConceptScore W3177139264C515207424 @default.
• W3177139264 hasConceptScore W3177139264C55493867 @default.
• W3177139264 hasConceptScore W3177139264C62231903 @default.
• W3177139264 hasConceptScore W3177139264C71924100 @default.
• W3177139264 hasConceptScore W3177139264C86803240 @default.

• next