Matches in SemOpenAlex for { <https://semopenalex.org/work/W3177150916> ?p ?o ?g. }
- W3177150916 abstract "CD1c presents lipid-based antigens to CD1c-restricted T cells, which are thought to be a major component of the human T cell pool. However, the study of CD1c-restricted T cells is hampered by the presence of an abundantly expressed, non-T cell receptor (TCR) ligand for CD1c on blood cells, confounding analysis of TCR-mediated CD1c tetramer staining. Here, we identified the CD36 family (CD36, SR-B1, and LIMP-2) as ligands for CD1c, CD1b, and CD1d proteins and showed that CD36 is the receptor responsible for non-TCR-mediated CD1c tetramer staining of blood cells. Moreover, CD36 blockade clarified tetramer-based identification of CD1c-restricted T cells and improved identification of CD1b- and CD1d-restricted T cells. We used this technique to characterize CD1c-restricted T cells ex vivo and showed diverse phenotypic features, TCR repertoire, and antigen-specific subsets. Accordingly, this work will enable further studies into the biology of CD1 and human CD1-restricted T cells." @default.
- W3177150916 created "2021-07-05" @default.
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- W3177150916 date "2021-06-15" @default.
- W3177150916 modified "2023-09-26" @default.
- W3177150916 title "CD36 family members are TCR-independent ligands for CD1 antigen–presenting molecules" @default.
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- W3177150916 doi "https://doi.org/10.1126/sciimmunol.abg4176" @default.
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