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• W3177171008 abstract "To investigate the clinical feasibility of single-breath-hold (SBH) T2-weighted (T2WI) liver MRI with deep learning-based reconstruction in the evaluation of image quality and lesion delineation, compared with conventional multi-breath-hold (MBH) T2WI. One hundred and fifty-two adult patients with suspected liver disease were prospectively enrolled. Two independent readers reviewed images acquired with conventional MBH-T2WI and SBH-T2WI at 3.0 T MR scanner. For image quality analyses, motion artifacts scores and boundary sharpness scores were compared using nonparametric Wilcoxon matched pairs tests between MBH-T2WI and SBH-T2WI. With the reference standard, 89 patients with 376 index lesions were included for lesion analyses. The lesion detection rates were compared by chi-square test, the lesion conspicuity scores and lesion-liver contrast ratio (CR) were compared using nonparametric Wilcoxon matched pairs tests between the two sequences. For both readers, motion artifacts scores of SBH-T2WI were significantly lower than MBH-T2WI ( P < 0.001). Boundary sharpness scores of SBH-T2WI were significantly higher than MBH-T2WI ( P < 0.001). The lesion detection rates for SBH-T2WI were significantly higher than MBH-T2WI ( P < 0.001); the differences of lesion detection rates between the two sequences were statistically significant for small (≤ 10 mm) liver lesions ( P < 0.001), while not significant for larger (> 10 mm) lesions ( P > 0.05). Lesion conspicuity scores were significantly higher on SBH-T2WI than MBH-T2WI in the entire cohort as well as in both stratified subgroups of lesions ≤10 mm and > 10 mm ( P < 0.001 for all). CRs for focal liver lesions were also significantly higher with SBH-T2WI ( P < 0.001). The SBH-T2WI sequence with deep-learning based reconstruction showed promising performance as it provided significantly better image quality, lesion detectability, lesion conspicuity and contrast within a single breath-hold, compared with the conventional MBH-T2WI. • SBH-T2WI provides better image quality and lesion delineation compared with MBH-T2WI. • SBH-T2WI reduces acquisition time significantly within a single breath-hold. • SBH-T2WI may become a standard protocol for future liver MRI." @default.
• W3177171008 created "2021-07-05" @default.
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• W3177171008 date "2021-09-01" @default.
• W3177171008 modified "2023-09-29" @default.
• W3177171008 title "Single-breath-hold T2WI liver MRI with deep learning-based reconstruction: A clinical feasibility study in comparison to conventional multi-breath-hold T2WI liver MRI" @default.
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• W3177171008 doi "https://doi.org/10.1016/j.mri.2021.06.014" @default.
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