FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3177189942> ?p ?o ?g. }

• W3177189942 abstract "Background: The real-world effectiveness of oxaliplatin in stage III colon cancer has not been determined in a large-scale population. We aimed to assess the real-world impact of adjuvant oxaliplatin treatment on the survival of these patients. Methods: Based on Taiwan cancer registry, we evaluated 17,801 patients with resected stage III colon cancer, including 14,168 patients receiving adjuvant chemotherapy and 3,633 not receiving adjuvant chemotherapy as the control group between 2004 and 2014. We used the controlled interrupted time-series analysis to assess the three-year disease-free survival and five-year overall survival rates before (2004–2008) and after (2009–2014) the addition of oxaliplatin. Results: The introduction of oxaliplatin was associated with no significant improvement in the slopes (per half-year) of the three-year disease-free survival rate (0.2%, 95% CI: −1.7∼2.2%) and five-year overall survival rate (0.6%, 95% CI: −1.8∼3%). The patients receiving oxaliplatin-based chemotherapy also showed no significant increase in the slopes (per half-year) of the three-year disease-free survival rate (0.6%, 95% CI: −1.4∼2.6%) and five-year overall survival rate (1%, 95% CI: −1.5∼3.5%). The nonsignificant results were consistent across subgroup analyses of age (&lt;70 vs. ≥70 years), recurrence risk (T1-3 or N1 vs. T4 or N2), and cycle of oxaliplatin use (≤6 vs. &gt;6). However, oxaliplatin-based chemotherapy significantly increased the slope (per half-year) of the five-year OS (2%, 95% CI: 0.2∼3.8%) for patients in the high-risk group (T4 or N2). The present results were robust in several sensitivity analyses. Conclusion: Among real-world patients with stage III colon cancer, the introduction of oxaliplatin does not yield a significant improvement in survival. Future work should identify the subpopulation(s) of patients who benefit significantly from the addition of oxaliplatin." @default.
• W3177189942 created "2021-07-05" @default.
• W3177189942 creator A5004913185 @default.
• W3177189942 creator A5024024448 @default.
• W3177189942 creator A5025201951 @default.
• W3177189942 creator A5025361204 @default.
• W3177189942 creator A5027932918 @default.
• W3177189942 creator A5041593760 @default.
• W3177189942 creator A5053209984 @default.
• W3177189942 creator A5054050349 @default.
• W3177189942 creator A5054485750 @default.
• W3177189942 creator A5055676410 @default.
• W3177189942 date "2021-06-29" @default.
• W3177189942 modified "2023-10-02" @default.
• W3177189942 title "Real-World Effectiveness of Adjuvant Oxaliplatin Chemotherapy in Stage III Colon Cancer: A Controlled Interrupted Time Series Analysis" @default.
• W3177189942 cites W1960485012 @default.
• W3177189942 cites W1972783815 @default.
• W3177189942 cites W2007844116 @default.
• W3177189942 cites W2056108924 @default.
• W3177189942 cites W2077618811 @default.
• W3177189942 cites W2100258195 @default.
• W3177189942 cites W2102840015 @default.
• W3177189942 cites W2111366073 @default.
• W3177189942 cites W2120871118 @default.
• W3177189942 cites W2125513842 @default.
• W3177189942 cites W2128628626 @default.
• W3177189942 cites W2138309253 @default.
• W3177189942 cites W2138446143 @default.
• W3177189942 cites W2138985803 @default.
• W3177189942 cites W2144495943 @default.
• W3177189942 cites W2145093498 @default.
• W3177189942 cites W2147407874 @default.
• W3177189942 cites W2158257131 @default.
• W3177189942 cites W2159187753 @default.
• W3177189942 cites W2169925647 @default.
• W3177189942 cites W2260992463 @default.
• W3177189942 cites W2301997220 @default.
• W3177189942 cites W2302003756 @default.
• W3177189942 cites W2416547532 @default.
• W3177189942 cites W2417978719 @default.
• W3177189942 cites W2524637936 @default.
• W3177189942 cites W2613716330 @default.
• W3177189942 cites W2751152798 @default.
• W3177189942 cites W2784300866 @default.
• W3177189942 cites W2795004907 @default.
• W3177189942 cites W2806350207 @default.
• W3177189942 cites W2883904009 @default.
• W3177189942 cites W2889646458 @default.
• W3177189942 cites W2897271346 @default.
• W3177189942 cites W2913253891 @default.
• W3177189942 cites W2935820515 @default.
• W3177189942 cites W3029838528 @default.
• W3177189942 doi "https://doi.org/10.3389/fphar.2021.693009" @default.
• W3177189942 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8276019" @default.
• W3177189942 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34267662" @default.
• W3177189942 hasPublicationYear "2021" @default.
• W3177189942 type Work @default.
• W3177189942 sameAs 3177189942 @default.
• W3177189942 citedByCount "4" @default.
• W3177189942 countsByYear W31771899422022 @default.
• W3177189942 countsByYear W31771899422023 @default.
• W3177189942 crossrefType "journal-article" @default.
• W3177189942 hasAuthorship W3177189942A5004913185 @default.
• W3177189942 hasAuthorship W3177189942A5024024448 @default.
• W3177189942 hasAuthorship W3177189942A5025201951 @default.
• W3177189942 hasAuthorship W3177189942A5025361204 @default.
• W3177189942 hasAuthorship W3177189942A5027932918 @default.
• W3177189942 hasAuthorship W3177189942A5041593760 @default.
• W3177189942 hasAuthorship W3177189942A5053209984 @default.
• W3177189942 hasAuthorship W3177189942A5054050349 @default.
• W3177189942 hasAuthorship W3177189942A5054485750 @default.
• W3177189942 hasAuthorship W3177189942A5055676410 @default.
• W3177189942 hasBestOaLocation W31771899421 @default.
• W3177189942 hasConcept C121608353 @default.
• W3177189942 hasConcept C126322002 @default.
• W3177189942 hasConcept C141071460 @default.
• W3177189942 hasConcept C143998085 @default.
• W3177189942 hasConcept C2776283816 @default.
• W3177189942 hasConcept C2776694085 @default.
• W3177189942 hasConcept C2777982462 @default.
• W3177189942 hasConcept C2778527826 @default.
• W3177189942 hasConcept C2780962732 @default.
• W3177189942 hasConcept C2908647359 @default.
• W3177189942 hasConcept C526805850 @default.
• W3177189942 hasConcept C71924100 @default.
• W3177189942 hasConcept C90924648 @default.
• W3177189942 hasConcept C99454951 @default.
• W3177189942 hasConceptScore W3177189942C121608353 @default.
• W3177189942 hasConceptScore W3177189942C126322002 @default.
• W3177189942 hasConceptScore W3177189942C141071460 @default.
• W3177189942 hasConceptScore W3177189942C143998085 @default.
• W3177189942 hasConceptScore W3177189942C2776283816 @default.
• W3177189942 hasConceptScore W3177189942C2776694085 @default.
• W3177189942 hasConceptScore W3177189942C2777982462 @default.
• W3177189942 hasConceptScore W3177189942C2778527826 @default.
• W3177189942 hasConceptScore W3177189942C2780962732 @default.
• W3177189942 hasConceptScore W3177189942C2908647359 @default.
• W3177189942 hasConceptScore W3177189942C526805850 @default.
• W3177189942 hasConceptScore W3177189942C71924100 @default.
• W3177189942 hasConceptScore W3177189942C90924648 @default.

• next