FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3177229340> ?p ?o ?g. }

• W3177229340 abstract "Abstract Peste des petits ruminants virus (PPRV) causes disease in domestic and wild ungulates, is the target of a global eradication programme and threatens biodiversity. Understanding the epidemiology and evolution of PPRV in wildlife is important, but hampered by the paucity of wildlife-origin PPRV genomes. In this study, full PPRV genomes were generated from three Mongolian saiga antelope, one Siberian ibex and one goitered gazelle from the 2016-2017 PPRV outbreak. Phylogenetic analysis showed that for Mongolian and Chinese PPRV since 2013, the wildlife and livestock-origin genomes were closely related and interspersed. There was strong phylogenetic support for a monophyletic group of PPRV from Mongolian wildlife and livestock, belonging to clade of lineage IV PPRV from livestock and wildlife from China since 2013. Discrete diffusion analysis found strong support for PPRV spread into Mongolia from China and phylogeographic analysis indicated Xinjiang Province as the most likely origin, although genomic surveillance for PPRV is poor and lack of sampling from other regions could bias this result. Times of most recent common ancestor (TMRCA) were June 2015 (95% HPD: August 2014 – March 2016) for all Mongolian PPRV genomes and May 2016 (95% HPD: October 2015 – October 2016) for Mongolian wildlife-origin PPRV. This suggests that PPRV was circulating undetected in Mongolia for at least six months before the first reported outbreak in August 2016, and that wildlife were likely infected before livestock vaccination began in October 2016. Finally, genetic variation and positively-selected sites were identified that might be related to PPRV emergence in Mongolian wildlife. This study is the first to sequence multiple PPRV genomes from a wildlife outbreak, across several host species. Additional full PPRV genomes and associated metadata from the livestock-wildlife interface are needed to enhance the power of molecular epidemiology, support PPRV eradication and safeguard the health of the whole ungulate community. Author Summary Recent mass mortality of critically endangered Mongolian saiga antelope due to peste des petits ruminants virus (PPRV) has dramatically highlighted the threat this viral disease represents for biodiversity. The genome of viruses such as PPRV evolve fast, so virus genetic data gathered from infected animals can be used to trace disease spread between livestock and wildlife, and to determine if the virus is adapting to infect wildlife more efficiently. Here we obtained PPRV virus genomes from Mongolian wildlife and compared them with other published PPRV genomes. Using a molecular clock, we estimated that the disease was circulating in Mongolia well before it was first reported. Genetic analyses support the hypothesis of virus spread from livestock to wildlife, with genetic changes potentially helping infection in Asian wild ungulates. However, more PPR virus genomes and epidemiology data are needed from disease outbreaks in areas shared between livestock and wildlife to confirm these results and take efficient actions to safeguard the health of the whole ungulate community." @default.
• W3177229340 created "2021-07-05" @default.
• W3177229340 creator A5023330506 @default.
• W3177229340 creator A5051028538 @default.
• W3177229340 creator A5054116478 @default.
• W3177229340 creator A5055470504 @default.
• W3177229340 creator A5065830204 @default.
• W3177229340 creator A5067413748 @default.
• W3177229340 creator A5068652062 @default.
• W3177229340 creator A5071166141 @default.
• W3177229340 creator A5072698090 @default.
• W3177229340 date "2021-05-08" @default.
• W3177229340 modified "2023-09-23" @default.
• W3177229340 title "Molecular epidemiology of peste des petits ruminants virus emergence in critically endangered Mongolian saiga antelope and other wild ungulates" @default.
• W3177229340 cites W1605220975 @default.
• W3177229340 cites W1892440676 @default.
• W3177229340 cites W1963681795 @default.
• W3177229340 cites W1973893727 @default.
• W3177229340 cites W1989838882 @default.
• W3177229340 cites W1992693335 @default.
• W3177229340 cites W1995873333 @default.
• W3177229340 cites W1996213870 @default.
• W3177229340 cites W1997075862 @default.
• W3177229340 cites W2002161186 @default.
• W3177229340 cites W2002535563 @default.
• W3177229340 cites W2014242384 @default.
• W3177229340 cites W2022628689 @default.
• W3177229340 cites W2044044562 @default.
• W3177229340 cites W2045949302 @default.
• W3177229340 cites W2060809301 @default.
• W3177229340 cites W2061337020 @default.
• W3177229340 cites W2076617993 @default.
• W3177229340 cites W2080284639 @default.
• W3177229340 cites W2086040645 @default.
• W3177229340 cites W2088818739 @default.
• W3177229340 cites W2093126481 @default.
• W3177229340 cites W2094939159 @default.
• W3177229340 cites W2099093910 @default.
• W3177229340 cites W2108234281 @default.
• W3177229340 cites W2108512869 @default.
• W3177229340 cites W2118982822 @default.
• W3177229340 cites W2120902911 @default.
• W3177229340 cites W2127774996 @default.
• W3177229340 cites W2132000705 @default.
• W3177229340 cites W2136847298 @default.
• W3177229340 cites W2159238558 @default.
• W3177229340 cites W2160364329 @default.
• W3177229340 cites W2165645673 @default.
• W3177229340 cites W2166573430 @default.
• W3177229340 cites W2167497350 @default.
• W3177229340 cites W2170565120 @default.
• W3177229340 cites W2171126517 @default.
• W3177229340 cites W2217507497 @default.
• W3177229340 cites W2229205130 @default.
• W3177229340 cites W2277792523 @default.
• W3177229340 cites W2311203695 @default.
• W3177229340 cites W2313961127 @default.
• W3177229340 cites W2322358787 @default.
• W3177229340 cites W2336475824 @default.
• W3177229340 cites W2341341327 @default.
• W3177229340 cites W2409599740 @default.
• W3177229340 cites W2473294541 @default.
• W3177229340 cites W2501688844 @default.
• W3177229340 cites W2560057613 @default.
• W3177229340 cites W2560780435 @default.
• W3177229340 cites W2571673310 @default.
• W3177229340 cites W2593881496 @default.
• W3177229340 cites W2614668429 @default.
• W3177229340 cites W2725620445 @default.
• W3177229340 cites W2739464432 @default.
• W3177229340 cites W2763935395 @default.
• W3177229340 cites W2781938185 @default.
• W3177229340 cites W2801159594 @default.
• W3177229340 cites W2802880935 @default.
• W3177229340 cites W2805453077 @default.
• W3177229340 cites W2807308836 @default.
• W3177229340 cites W2883078165 @default.
• W3177229340 cites W2884445228 @default.
• W3177229340 cites W2890222269 @default.
• W3177229340 cites W2897199543 @default.
• W3177229340 cites W2900386172 @default.
• W3177229340 cites W2919645370 @default.
• W3177229340 cites W2945402467 @default.
• W3177229340 cites W2948096480 @default.
• W3177229340 cites W2953596016 @default.
• W3177229340 cites W2956359175 @default.
• W3177229340 cites W2956416651 @default.
• W3177229340 cites W2969201059 @default.
• W3177229340 cites W2992847461 @default.
• W3177229340 cites W2995432534 @default.
• W3177229340 cites W2995774433 @default.
• W3177229340 cites W2999243545 @default.
• W3177229340 cites W3007335672 @default.
• W3177229340 cites W3009831701 @default.
• W3177229340 cites W3010813558 @default.
• W3177229340 cites W3016634513 @default.
• W3177229340 cites W3041125688 @default.
• W3177229340 cites W3102683979 @default.
• W3177229340 cites W3110016503 @default.
• W3177229340 cites W3135298613 @default.

• next