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• W3177367980 abstract "Relapse is a major obstacle to curb the ongoing epidemic of prescription opioid abuse. We and others previously demonstrated that oxycodone seeking in adult rats progressively increases after abstinence from oxycodone self-administration (incubation of oxycodone craving). In humans, the onset of oxycodone use in adolescents may increase individuals’ vulnerability to later opioid addiction. However, little is known about incubation of oxycodone craving after adolescent-onset oxycodone self-administration in rats. In the first study, we trained single-housed adolescent (postnatal day 35 at start) and adult (postnatal day 77 at start) male Sprague–Dawley rats to self-administer oxycodone (0.1 mg/kg/infusion, 6 h/day for 10 days) and then tested oxycodone relapse on both abstinence day 1 and day 15. Given that social experience is critical for neurobehavioral development in adolescents, we performed the second study using group-housed adolescent and adult rats. In both studies, we observed no age differences in oxycodone self-administration and incubated oxycodone seeking on abstinence day 15. However, on abstinence day 1, we observed decreased oxycodone seeking in adolescents compared with adults. This pattern of data led to elevated incubation slopes in adolescent rats compared with adult rats. Finally, group-housed rats exhibited attenuated oxycodone seeking compared with single-housed rats on abstinence day 15, but not on day 1. Taken together, these data suggest that adolescents may be resistant to oxycodone relapse during early abstinence, but this resistance dissipates quickly during the transition between adolescent and young adulthood. In addition, group-housing plays a protective role against incubated oxycodone craving." @default.
• W3177367980 created "2021-07-05" @default.
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• W3177367980 date "2021-06-23" @default.
• W3177367980 modified "2023-10-01" @default.
• W3177367980 title "Incubation of Oxycodone Craving Following Adult-Onset and Adolescent-Onset Oxycodone Self-Administration in Male Rats" @default.
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• W3177367980 cites W1980335563 @default.
• W3177367980 cites W1985645068 @default.
• W3177367980 cites W1988965958 @default.
• W3177367980 cites W1991515600 @default.
• W3177367980 cites W1992208327 @default.
• W3177367980 cites W1993276142 @default.
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• W3177367980 cites W1996987711 @default.
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• W3177367980 cites W1999630081 @default.
• W3177367980 cites W2001195560 @default.
• W3177367980 cites W2002283510 @default.
• W3177367980 cites W2006755682 @default.
• W3177367980 cites W2006999172 @default.
• W3177367980 cites W2010427677 @default.
• W3177367980 cites W2017089625 @default.
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• W3177367980 cites W2024870933 @default.
• W3177367980 cites W2037854852 @default.
• W3177367980 cites W2040975718 @default.
• W3177367980 cites W2042897662 @default.
• W3177367980 cites W2045468354 @default.
• W3177367980 cites W2049264784 @default.
• W3177367980 cites W2051028855 @default.
• W3177367980 cites W2053058520 @default.
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• W3177367980 cites W2055286116 @default.
• W3177367980 cites W2056397792 @default.
• W3177367980 cites W2057348335 @default.
• W3177367980 cites W2059180163 @default.
• W3177367980 cites W2064693618 @default.
• W3177367980 cites W2070183905 @default.
• W3177367980 cites W2076412383 @default.
• W3177367980 cites W2087309661 @default.
• W3177367980 cites W2091784879 @default.
• W3177367980 cites W2111911328 @default.
• W3177367980 cites W2159841381 @default.
• W3177367980 cites W2171592578 @default.
• W3177367980 cites W2173720074 @default.
• W3177367980 cites W2345672368 @default.
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• W3177367980 cites W2515243998 @default.
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• W3177367980 cites W2754273660 @default.
• W3177367980 cites W2765501940 @default.
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• W3177367980 cites W2911167149 @default.
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• W3177367980 doi "https://doi.org/10.3389/fnbeh.2021.697509" @default.
• W3177367980 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8262493" @default.
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• W3177367980 hasPublicationYear "2021" @default.
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