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• W3177410081 abstract "Abstract Organisms in the wild can acquire disease and stress resistance traits that far outstrip the programs endogenous to humans. Finding the molecular basis of such natural resistance characters is a key goal of evolutionary genetics. Standard statistical-genetic methods toward this end can perform poorly in organismal systems that lack high rates of meiotic recombination, like Caenorhabditis worms. Here we discovered unique ER stress resistance in a Kenyan C. elegans isolate, which in inter-strain crosses was passed by hermaphrodite mothers to hybrid offspring. We developed an unbiased version of the reciprocal hemizygosity test, RH-seq, to explore the genetics of this parent-of-origin-dependent phenotype. Among top-scoring gene candidates from a partial-coverage RH-seq screen, we focused on the neuronally-expressed, cuticlin-like gene cutl-24 for validation. In gene disruption and controlled crossing experiments, we found that cutl-24 was required in Kenyan hermaphrodite mothers for ER stress tolerance in their inter-strain hybrid offspring, and was a contributor to the trait in their purebred progeny. These data establish the Kenyan strain allele of cutl-24 as a determinant of a natural stress-resistant state, and they set a precedent for the dissection of natural trait diversity in invertebrate animals without the need for a panel of meiotic recombinants." @default.
• W3177410081 created "2021-07-05" @default.
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• W3177410081 date "2021-07-01" @default.
• W3177410081 modified "2023-10-16" @default.
• W3177410081 title "A role for worm cutl-24 in background- and parent-of-origin-dependent ER stress resistance" @default.
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• W3177410081 doi "https://doi.org/10.1101/2021.07.01.450736" @default.
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