FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3177448370> ?p ?o ?g. }

• W3177448370 endingPage "2712" @default.
• W3177448370 startingPage "2697" @default.
• W3177448370 abstract "Donor-specific antibodies (DSA) against donor human leukocyte antigen after liver transplantation, which are associated with histological changes, have been widely studied with respect to their sustained impact on transplant function. However, their long-term impact after liver transplantation remains unclear.We performed a cross-sectional analysis from June 2016 to July 2017 that included all patients who presented themselves for scheduled follow-up after receiving a liver transplantation between September 1989 and December 2016. In addition to a liver protocol biopsy, patients were screened for human leukocyte antigen antibodies (HLAab) and donor-specific antibodies. Subsequently, the association between human leukocyte antigen antibodies, donor-specific antibodies, histologic and clinical features, and immunosuppression was analyzed.Analysis for human leukocyte antigen antibodies and donor-specific antibodies against donor human leukocyte antigen was performed for 291 and 271 patients. A significant association between higher inflammation grades and the presence of human leukocyte antigen antibodies and donor-specific antibodies was detected, while fibrosis stages remained unaffected. These results were confirmed by multivariate logistic regression for inflammation showing a significant increase for presence of human leukocyte antigen antibodies and donor-specific antibodies (OR: 4.43; 95% CI: 1.67-12.6; p=0.0035). Furthermore, the use of everolimus in combination with tacrolimus was significantly associated with the status of negative human leukocyte antigen antibodies and donor-specific antibodies. Viral etiology for liver disease, hepatocellular carcinoma (HCC) and higher steatosis grades of the graft were significantly associated with a lower rate of human leukocyte antigen antibodies. The impact of human leukocyte antigen antibodies and donor-specific antibodies against donor human leukocyte antigen was associated with higher levels of laboratory parameters, such as transaminases and bilirubin.Donor-specific antibodies against donor human leukocyte antigen are associated with histological and biochemical graft inflammation after liver transplantation, while fibrosis seems to be unaffected. Future studies should validate these findings for longer observation periods and specific subgroups." @default.
• W3177448370 created "2021-07-05" @default.
• W3177448370 creator A5015952778 @default.
• W3177448370 creator A5026891294 @default.
• W3177448370 creator A5030024392 @default.
• W3177448370 creator A5033636816 @default.
• W3177448370 creator A5048818174 @default.
• W3177448370 creator A5050190020 @default.
• W3177448370 creator A5051146663 @default.
• W3177448370 creator A5053029127 @default.
• W3177448370 creator A5054668912 @default.
• W3177448370 creator A5056017342 @default.
• W3177448370 creator A5066753190 @default.
• W3177448370 creator A5070494503 @default.
• W3177448370 creator A5076322082 @default.
• W3177448370 creator A5083825910 @default.
• W3177448370 creator A5085883112 @default.
• W3177448370 date "2021-06-01" @default.
• W3177448370 modified "2023-09-29" @default.
• W3177448370 title "Donor-Specific Antibodies Against Donor Human Leukocyte Antigen are Associated with Graft Inflammation but Not with Fibrosis Long-Term After Liver Transplantation: An Analysis of Protocol Biopsies" @default.
• W3177448370 cites W1483805491 @default.
• W3177448370 cites W1492421523 @default.
• W3177448370 cites W1528026588 @default.
• W3177448370 cites W1541334566 @default.
• W3177448370 cites W1559751337 @default.
• W3177448370 cites W1602515044 @default.
• W3177448370 cites W1721162241 @default.
• W3177448370 cites W1955591537 @default.
• W3177448370 cites W1993332611 @default.
• W3177448370 cites W2018862780 @default.
• W3177448370 cites W2034406655 @default.
• W3177448370 cites W2047292563 @default.
• W3177448370 cites W2055572351 @default.
• W3177448370 cites W2059777084 @default.
• W3177448370 cites W2070731552 @default.
• W3177448370 cites W2076571742 @default.
• W3177448370 cites W2076789595 @default.
• W3177448370 cites W2097192629 @default.
• W3177448370 cites W2107180815 @default.
• W3177448370 cites W2117821771 @default.
• W3177448370 cites W2120205280 @default.
• W3177448370 cites W2122930177 @default.
• W3177448370 cites W2126368995 @default.
• W3177448370 cites W2137969636 @default.
• W3177448370 cites W2140930399 @default.
• W3177448370 cites W2150661866 @default.
• W3177448370 cites W2159954692 @default.
• W3177448370 cites W2165334685 @default.
• W3177448370 cites W2167926698 @default.
• W3177448370 cites W2273605374 @default.
• W3177448370 cites W2284266723 @default.
• W3177448370 cites W2286890146 @default.
• W3177448370 cites W2293826568 @default.
• W3177448370 cites W2313397819 @default.
• W3177448370 cites W2329992269 @default.
• W3177448370 cites W2410717006 @default.
• W3177448370 cites W2418954789 @default.
• W3177448370 cites W2531067979 @default.
• W3177448370 cites W2598403659 @default.
• W3177448370 cites W2769575754 @default.
• W3177448370 cites W2770166435 @default.
• W3177448370 cites W2799553518 @default.
• W3177448370 cites W2802957100 @default.
• W3177448370 cites W2898753264 @default.
• W3177448370 cites W2943755422 @default.
• W3177448370 cites W2982050181 @default.
• W3177448370 cites W2993908729 @default.
• W3177448370 cites W2998714327 @default.
• W3177448370 cites W3009615357 @default.
• W3177448370 cites W3082562253 @default.
• W3177448370 cites W3083759464 @default.
• W3177448370 cites W3093372607 @default.
• W3177448370 doi "https://doi.org/10.2147/jir.s307778" @default.
• W3177448370 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8236257" @default.
• W3177448370 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34188517" @default.
• W3177448370 hasPublicationYear "2021" @default.
• W3177448370 type Work @default.
• W3177448370 sameAs 3177448370 @default.
• W3177448370 citedByCount "4" @default.
• W3177448370 countsByYear W31774483702022 @default.
• W3177448370 countsByYear W31774483702023 @default.
• W3177448370 crossrefType "journal-article" @default.
• W3177448370 hasAuthorship W3177448370A5015952778 @default.
• W3177448370 hasAuthorship W3177448370A5026891294 @default.
• W3177448370 hasAuthorship W3177448370A5030024392 @default.
• W3177448370 hasAuthorship W3177448370A5033636816 @default.
• W3177448370 hasAuthorship W3177448370A5048818174 @default.
• W3177448370 hasAuthorship W3177448370A5050190020 @default.
• W3177448370 hasAuthorship W3177448370A5051146663 @default.
• W3177448370 hasAuthorship W3177448370A5053029127 @default.
• W3177448370 hasAuthorship W3177448370A5054668912 @default.
• W3177448370 hasAuthorship W3177448370A5056017342 @default.
• W3177448370 hasAuthorship W3177448370A5066753190 @default.
• W3177448370 hasAuthorship W3177448370A5070494503 @default.
• W3177448370 hasAuthorship W3177448370A5076322082 @default.
• W3177448370 hasAuthorship W3177448370A5083825910 @default.
• W3177448370 hasAuthorship W3177448370A5085883112 @default.
• W3177448370 hasBestOaLocation W31774483701 @default.

• next