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• W3177453151 endingPage "1849" @default.
• W3177453151 startingPage "1839" @default.
• W3177453151 abstract "The epidemiology and treatment of peripheral neuropathy in systemic sclerosis (SSc) is poorly understood. The objectives of this study were to evaluate the incidence, prevalence, risk factors, and treatments of peripheral neuropathy in SSc.A systematic review of MEDLINE, Embase, and the Cumulative Index to Nursing and Allied Health Literature (CINAHL) databases for literature reporting peripheral neuropathy in SSc was performed. Studies evaluating incidence, prevalence, risk factors, and treatments were synthesized. A metaanalysis using a random effects model was used to evaluate the prevalence of peripheral neuropathy.This systematic review identified 113 studies that reported 949 of 2143 subjects with at least 1 type of peripheral neuropathy. The mean age was 48.5 years. The mean time between SSc onset and detection of peripheral neuropathy was 8.85 years. The pooled prevalence of neuropathy was 27.37% (95% CI 22.35-32.70). Risk factors for peripheral neuropathy in SSc included advanced diffuse disease, anticentromere antibodies, calcinosis cutis, ischemia of the vasa nervorum, iron deficiency anemia, metoclopramide, pembrolizumab, silicosis, and uremia. There were 73 subjects with successful treatments (n = 36 restoring sensation, n = 37 restoring motor or sensorimotor function). Treatments included decompression surgery, prednisone, cyclophosphamide, carbamazepine, transcutaneous electrical nerve stimulation, tricyclic antidepressants, and intravenous Ig.All-cause peripheral neuropathy is not uncommon in SSc. Compression neuropathies can be treated with decompression surgery. Observational data reporting immunosuppressives and anticonvulsants to treat peripheral neuropathy in SSc are limited and conflicting. Randomized controlled trials are needed to evaluate the efficacy of these interventions." @default.
• W3177453151 created "2021-07-05" @default.
• W3177453151 creator A5016584229 @default.
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• W3177453151 creator A5044307132 @default.
• W3177453151 creator A5074449935 @default.
• W3177453151 date "2021-07-01" @default.
• W3177453151 modified "2023-10-14" @default.
• W3177453151 title "Epidemiology and Treatment of Peripheral Neuropathy in Systemic Sclerosis" @default.
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• W3177453151 doi "https://doi.org/10.3899/jrheum.201299" @default.
• W3177453151 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34210833" @default.
• W3177453151 hasPublicationYear "2021" @default.
• W3177453151 type Work @default.

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