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- W3177454976 abstract "The objective of this research work is to characterize antiviral and anti-retrotransposon activity of RNA helicase Mov10. We recently reported that ectopic expression of Mov10 restricted the production of HIV-1 and other lentiviruses as well as the gammaretrovirus, murine leukemia virus. 293T cells were transfected with retrovirus coding plasmid and Mov10 or control plasmid followed by infectivity test. HIV produced in the presence of high levels of Mov10 is restricted at the pre-reverse transcription stage in target cells. To determine if Mov10 can also modulate transposition of retroviral elements in human genome, we transfected HeLa cells with retrotransposon coding plasmid that contained neomycin resistance cassette with or without Mov10 expressing plasmid. We then quantitated retrotransposon integration frequency by counting G418-resistant cellular colonies in the presence or absence of Mov10 transfection. Retrotransposition of LINE-1, MusD and IAP was significantly reduced by Mov10 in a dose dependent manner. These retroelements also showed sensitivity to restriction by other proteins found within the mRNA processing bodies (P-bodies) such as Ago-2 and Rent1. These findings suggest a potentially important role for cytoplasmic RNA processing machinery in retroviral infectivity, production and control of mobile genetic elements. This work was supported by NIH Grant R21 AI078839 to D.U." @default.
- W3177454976 created "2021-07-05" @default.
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- W3177454976 date "2011-04-01" @default.
- W3177454976 modified "2023-10-16" @default.
- W3177454976 title "RNA helicase Mov10 is a potent inhibitor of HIV or retrovirus infectivity and retrotransposition of endogenous mammalian retroviruses" @default.
- W3177454976 doi "https://doi.org/10.1096/fasebj.25.1_supplement.886.2" @default.
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