Matches in SemOpenAlex for { <https://semopenalex.org/work/W3177466125> ?p ?o ?g. }
- W3177466125 endingPage "1267" @default.
- W3177466125 startingPage "1267" @default.
- W3177466125 abstract "The rapid discovery of new and diverse bacteriophages has driven the innovation of approaches aimed at detailing interactions with their bacterial hosts. Previous studies on receptor binding proteins (RBPs) mainly relied on their identification in silico and are based on similarities to well-characterized systems. Thus, novel phage RBPs unlike those currently annotated in genomic and proteomic databases remain largely undiscovered. In this study, we employed a screen to identify RBPs in flagellotropic Agrobacterium phage 7-7-1. Flagellotropic phages utilize bacterial flagella as receptors. The screen identified three candidate RBPs, Gp4, Gp102, and Gp44. Homology modelling predicted that Gp4 is a trimeric, tail associated protein with a central β-barrel, while the structure and function of Gp102 and Gp44 are less obvious. Studies with purified Gp41-247 confirmed its ability to bind and interact with host cells, highlighting the robustness of the RBP screen. We also discovered that Gp41-247 inhibits the growth of host cells in a motility and lipopolysaccharide (LPS) dependent fashion. Hence, our results suggest interactions between Gp41-247, rotating flagellar filaments and host glycans to inhibit host cell growth, which presents an impactful and intriguing focus for future studies." @default.
- W3177466125 created "2021-07-05" @default.
- W3177466125 creator A5018420458 @default.
- W3177466125 creator A5069668753 @default.
- W3177466125 date "2021-06-29" @default.
- W3177466125 modified "2023-10-02" @default.
- W3177466125 title "Identification of Receptor Binding Proteins in Flagellotropic Agrobacterium Phage 7-7-1" @default.
- W3177466125 cites W1132795267 @default.
- W3177466125 cites W1554820849 @default.
- W3177466125 cites W1565742523 @default.
- W3177466125 cites W1803102843 @default.
- W3177466125 cites W1859583841 @default.
- W3177466125 cites W1906473861 @default.
- W3177466125 cites W1943327251 @default.
- W3177466125 cites W194917975 @default.
- W3177466125 cites W1965501216 @default.
- W3177466125 cites W1965976505 @default.
- W3177466125 cites W1986457803 @default.
- W3177466125 cites W1989073611 @default.
- W3177466125 cites W1999907982 @default.
- W3177466125 cites W2001272684 @default.
- W3177466125 cites W2019795239 @default.
- W3177466125 cites W2028998981 @default.
- W3177466125 cites W2047375636 @default.
- W3177466125 cites W2057193412 @default.
- W3177466125 cites W2062428434 @default.
- W3177466125 cites W2076764567 @default.
- W3177466125 cites W2078105092 @default.
- W3177466125 cites W2078307783 @default.
- W3177466125 cites W2080140469 @default.
- W3177466125 cites W2081272404 @default.
- W3177466125 cites W2088079518 @default.
- W3177466125 cites W2095943622 @default.
- W3177466125 cites W2099006829 @default.
- W3177466125 cites W2100100451 @default.
- W3177466125 cites W2119134855 @default.
- W3177466125 cites W2119445362 @default.
- W3177466125 cites W2123093603 @default.
- W3177466125 cites W2129434797 @default.
- W3177466125 cites W2130881268 @default.
- W3177466125 cites W2139779127 @default.
- W3177466125 cites W2144324577 @default.
- W3177466125 cites W2146877297 @default.
- W3177466125 cites W2153076508 @default.
- W3177466125 cites W2157660810 @default.
- W3177466125 cites W2158714788 @default.
- W3177466125 cites W2159306961 @default.
- W3177466125 cites W2163668511 @default.
- W3177466125 cites W2165001700 @default.
- W3177466125 cites W2212607938 @default.
- W3177466125 cites W2237832851 @default.
- W3177466125 cites W2316845643 @default.
- W3177466125 cites W2558551622 @default.
- W3177466125 cites W2603734291 @default.
- W3177466125 cites W2606475437 @default.
- W3177466125 cites W2666046300 @default.
- W3177466125 cites W2762374987 @default.
- W3177466125 cites W2768649360 @default.
- W3177466125 cites W2769071465 @default.
- W3177466125 cites W2781564139 @default.
- W3177466125 cites W2804822363 @default.
- W3177466125 cites W2884258138 @default.
- W3177466125 cites W2910246763 @default.
- W3177466125 cites W2911362701 @default.
- W3177466125 cites W2949853177 @default.
- W3177466125 cites W2960892262 @default.
- W3177466125 cites W2982302744 @default.
- W3177466125 cites W3011628947 @default.
- W3177466125 cites W3023787861 @default.
- W3177466125 cites W3042841501 @default.
- W3177466125 cites W3048158379 @default.
- W3177466125 cites W3095316276 @default.
- W3177466125 cites W3110680411 @default.
- W3177466125 cites W3126407166 @default.
- W3177466125 cites W3137740529 @default.
- W3177466125 cites W4234714728 @default.
- W3177466125 cites W4241163803 @default.
- W3177466125 doi "https://doi.org/10.3390/v13071267" @default.
- W3177466125 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8310070" @default.
- W3177466125 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34209785" @default.
- W3177466125 hasPublicationYear "2021" @default.
- W3177466125 type Work @default.
- W3177466125 sameAs 3177466125 @default.
- W3177466125 citedByCount "6" @default.
- W3177466125 countsByYear W31774661252022 @default.
- W3177466125 countsByYear W31774661252023 @default.
- W3177466125 crossrefType "journal-article" @default.
- W3177466125 hasAuthorship W3177466125A5018420458 @default.
- W3177466125 hasAuthorship W3177466125A5069668753 @default.
- W3177466125 hasBestOaLocation W31774661251 @default.
- W3177466125 hasConcept C104317684 @default.
- W3177466125 hasConcept C115811362 @default.
- W3177466125 hasConcept C169627665 @default.
- W3177466125 hasConcept C181199279 @default.
- W3177466125 hasConcept C2775905019 @default.
- W3177466125 hasConcept C523546767 @default.
- W3177466125 hasConcept C54355233 @default.
- W3177466125 hasConcept C55493867 @default.