Matches in SemOpenAlex for { <https://semopenalex.org/work/W3177482252> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W3177482252 abstract "In vivo CD8+ T cell responses consist of three main phases, namely: (i) a proliferation phase consisting of effector T cell clonal expansion, (ii) a contraction (transition) phase leading to the transition from the large population of effector T cells to a smaller population of long-lived memory T (Tm) cells, and (iii) a maintenance phase involving Tm cell survival in the host. Recently, it has also been shown that IL-12 priming during in vitro Ag stimulation changes properties of CD8+ T cells such as downregulation of CD69, alteration in the distribution of lipid rafts, a decrease in T cell receptor structural avidity and cytolytic activity. However, the potent functional property of CD8+ Tm cells without IL-12 priming for secondary expansion upon Ag reencounter is still unclear.In this study, we attempted to clarify the role of IL-12 by transferring the CD8+ effector T cells into wild-type C57BL/6 and IL-12 gene KO mice, respectively. Our findings showed that IL-12 priming is important not only in CD8+ T cell clonal expansion in the proliferation phase, but also in generation of CD8+ Tm cells with the capacity of secondary expansion upon antigen re-encounter. However, IL-12 signaling is neither involved in CD8+ effector T cell survival in the transition phase nor in the CD8+ Tm cell's secondary expansion in recall responses." @default.
- W3177482252 created "2021-07-05" @default.
- W3177482252 creator A5050511969 @default.
- W3177482252 date "2008-03-01" @default.
- W3177482252 modified "2023-09-26" @default.
- W3177482252 title "Defective capacity of CD8+ memory T cells developed from absence of IL‐12 priming for secondary expansion" @default.
- W3177482252 doi "https://doi.org/10.1096/fasebj.22.1_supplement.1122.10" @default.
- W3177482252 hasPublicationYear "2008" @default.
- W3177482252 type Work @default.
- W3177482252 sameAs 3177482252 @default.
- W3177482252 citedByCount "0" @default.
- W3177482252 crossrefType "journal-article" @default.
- W3177482252 hasAuthorship W3177482252A5050511969 @default.
- W3177482252 hasConcept C100701293 @default.
- W3177482252 hasConcept C147483822 @default.
- W3177482252 hasConcept C154317977 @default.
- W3177482252 hasConcept C167672396 @default.
- W3177482252 hasConcept C185592680 @default.
- W3177482252 hasConcept C202751555 @default.
- W3177482252 hasConcept C203014093 @default.
- W3177482252 hasConcept C2776090121 @default.
- W3177482252 hasConcept C2777367678 @default.
- W3177482252 hasConcept C2908647359 @default.
- W3177482252 hasConcept C51785407 @default.
- W3177482252 hasConcept C55493867 @default.
- W3177482252 hasConcept C59822182 @default.
- W3177482252 hasConcept C71924100 @default.
- W3177482252 hasConcept C79484868 @default.
- W3177482252 hasConcept C81444415 @default.
- W3177482252 hasConcept C86803240 @default.
- W3177482252 hasConcept C8891405 @default.
- W3177482252 hasConcept C95444343 @default.
- W3177482252 hasConcept C99454951 @default.
- W3177482252 hasConceptScore W3177482252C100701293 @default.
- W3177482252 hasConceptScore W3177482252C147483822 @default.
- W3177482252 hasConceptScore W3177482252C154317977 @default.
- W3177482252 hasConceptScore W3177482252C167672396 @default.
- W3177482252 hasConceptScore W3177482252C185592680 @default.
- W3177482252 hasConceptScore W3177482252C202751555 @default.
- W3177482252 hasConceptScore W3177482252C203014093 @default.
- W3177482252 hasConceptScore W3177482252C2776090121 @default.
- W3177482252 hasConceptScore W3177482252C2777367678 @default.
- W3177482252 hasConceptScore W3177482252C2908647359 @default.
- W3177482252 hasConceptScore W3177482252C51785407 @default.
- W3177482252 hasConceptScore W3177482252C55493867 @default.
- W3177482252 hasConceptScore W3177482252C59822182 @default.
- W3177482252 hasConceptScore W3177482252C71924100 @default.
- W3177482252 hasConceptScore W3177482252C79484868 @default.
- W3177482252 hasConceptScore W3177482252C81444415 @default.
- W3177482252 hasConceptScore W3177482252C86803240 @default.
- W3177482252 hasConceptScore W3177482252C8891405 @default.
- W3177482252 hasConceptScore W3177482252C95444343 @default.
- W3177482252 hasConceptScore W3177482252C99454951 @default.
- W3177482252 hasIssue "S1" @default.
- W3177482252 hasLocation W31774822521 @default.
- W3177482252 hasOpenAccess W3177482252 @default.
- W3177482252 hasPrimaryLocation W31774822521 @default.
- W3177482252 hasRelatedWork W1491309847 @default.
- W3177482252 hasRelatedWork W1986222655 @default.
- W3177482252 hasRelatedWork W2081704009 @default.
- W3177482252 hasRelatedWork W2097271095 @default.
- W3177482252 hasRelatedWork W2134356477 @default.
- W3177482252 hasRelatedWork W2502297276 @default.
- W3177482252 hasRelatedWork W2952174619 @default.
- W3177482252 hasRelatedWork W4231268114 @default.
- W3177482252 hasRelatedWork W4243651954 @default.
- W3177482252 hasRelatedWork W4313351690 @default.
- W3177482252 hasVolume "22" @default.
- W3177482252 isParatext "false" @default.
- W3177482252 isRetracted "false" @default.
- W3177482252 magId "3177482252" @default.
- W3177482252 workType "article" @default.