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- W3177513281 abstract "The unmet demand for selective and remote detection of biological entities has urged nanobiotechnology to prioritize the innovation of biolabels that can be remotely detected. Magnetic nanowires (MNWs) have been deemed promising for remote detection as the magnetic fields can deeply and safely penetrate into tissue. However, the overlapping nature of the magnetic signatures has been a long-standing challenge for selective detection, which we resolve here. To do so, 13 types of MNWs with unique irreversible switching field (ISF) signatures were synthesized for labeling canine osteosarcoma (OSCA-8) cancer cells (one set) and polycarbonate biopolymers (12 sets). After characterizing the ISF signature of each MNW type, the MNW-labeled cancer cells were transferred onto MNW-labeled biopolymers to determine the most distinguishable ISF signatures and to discern the principles for reliable selective detection of biological entities. We show that tailoring the ISF of MNWs by tuning their coercivity is a highly effective approach for generating distinct magnetic biolabels for selective detection of cells. These findings smooth the path for the progression of nanobiotechnology by enabling the remote and selective detection of biological entities using MNWs." @default.
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- W3177513281 date "2021-07-07" @default.
- W3177513281 modified "2023-09-27" @default.
- W3177513281 title "Realizing the Principles for Remote and Selective Detection of Cancer Cells Using Magnetic Nanowires" @default.
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- W3177513281 doi "https://doi.org/10.1021/acs.jpcb.1c04394" @default.
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