FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3177562774> ?p ?o ?g. }

• W3177562774 endingPage "833" @default.
• W3177562774 startingPage "833" @default.
• W3177562774 abstract "Acinetobacter baumannii has become a serious threat to human health due to its extreme antibiotic resistance, environmental persistence, and capacity to survive within the host. Two A. baumannii strains, A118 and AB5075, commonly used as model systems, and three carbapenem-resistant strains, which are becoming ever more dangerous due to the multiple drugs they can resist, were exposed to 3.5% human serum albumin (HSA) and human serum (HS) to evaluate their response with respect to antimicrobial resistance, biofilm formation, and quorum sensing, all features responsible for increasing survival and persistence in the environment and human body. Expression levels of antibiotic resistance genes were modified differently when examined in different strains. The cmlA gene was upregulated or downregulated in conditions of exposure to 3.5% HSA or HS depending on the strain. Expression levels of pbp1 and pbp3 tended to be increased by the presence of HSA and HS, but the effect was not seen in all strains. A. baumannii A118 growing in the presence of HS did not experience increased expression of these genes. Aminoglycoside-modifying enzymes were also expressed at higher or lower levels in the presence of HSA or HS. Still, the response was not uniform; in some cases, expression was enhanced, and in other cases, it was tapered. While A. baumannii AB5075 became more susceptible to rifampicin in the presence of 3.5% HSA or HS, strain A118 did not show any changes. Expression of arr2, a gene involved in resistance to rifampicin present in A. baumannii AMA16, was expressed at higher levels when HS was present in the culture medium. HSA and HS reduced biofilm formation and production of N-Acyl Homoserine Lactone, a compound intimately associated with quorum sensing. In conclusion, HSA, the main component of HS, stimulates a variety of adaptative responses in infecting A. baumannii strains." @default.
• W3177562774 created "2021-07-19" @default.
• W3177562774 creator A5000611736 @default.
• W3177562774 creator A5005522906 @default.
• W3177562774 creator A5014959417 @default.
• W3177562774 creator A5026946798 @default.
• W3177562774 creator A5029196815 @default.
• W3177562774 creator A5076790643 @default.
• W3177562774 creator A5077568724 @default.
• W3177562774 creator A5090976729 @default.
• W3177562774 date "2021-07-08" @default.
• W3177562774 modified "2023-10-18" @default.
• W3177562774 title "Interaction of Acinetobacter baumannii with Human Serum Albumin: Does the Host Determine the Outcome?" @default.
• W3177562774 cites W1955626095 @default.
• W3177562774 cites W1988874714 @default.
• W3177562774 cites W1989896883 @default.
• W3177562774 cites W1992050565 @default.
• W3177562774 cites W2034825150 @default.
• W3177562774 cites W2086223988 @default.
• W3177562774 cites W2114686855 @default.
• W3177562774 cites W2115486016 @default.
• W3177562774 cites W2120667024 @default.
• W3177562774 cites W2120992606 @default.
• W3177562774 cites W2124804822 @default.
• W3177562774 cites W2126480284 @default.
• W3177562774 cites W2168519960 @default.
• W3177562774 cites W2329075805 @default.
• W3177562774 cites W2400828020 @default.
• W3177562774 cites W2578361705 @default.
• W3177562774 cites W2595486666 @default.
• W3177562774 cites W2603561245 @default.
• W3177562774 cites W2613215671 @default.
• W3177562774 cites W2758682842 @default.
• W3177562774 cites W2783017631 @default.
• W3177562774 cites W2784208000 @default.
• W3177562774 cites W2790591969 @default.
• W3177562774 cites W2790646736 @default.
• W3177562774 cites W2791790671 @default.
• W3177562774 cites W2792103240 @default.
• W3177562774 cites W2807661764 @default.
• W3177562774 cites W2892804103 @default.
• W3177562774 cites W2896374296 @default.
• W3177562774 cites W2897725639 @default.
• W3177562774 cites W2901603238 @default.
• W3177562774 cites W2901844117 @default.
• W3177562774 cites W2916887930 @default.
• W3177562774 cites W2924535331 @default.
• W3177562774 cites W2924739878 @default.
• W3177562774 cites W2934656438 @default.
• W3177562774 cites W2936662929 @default.
• W3177562774 cites W2944887126 @default.
• W3177562774 cites W2950651849 @default.
• W3177562774 cites W2951055935 @default.
• W3177562774 cites W2957299798 @default.
• W3177562774 cites W2990432986 @default.
• W3177562774 cites W2996376688 @default.
• W3177562774 cites W3008529652 @default.
• W3177562774 cites W3008567980 @default.
• W3177562774 cites W3019886680 @default.
• W3177562774 cites W3091114892 @default.
• W3177562774 cites W3092383626 @default.
• W3177562774 cites W3122807611 @default.
• W3177562774 cites W3127586556 @default.
• W3177562774 cites W3129270450 @default.
• W3177562774 cites W3137038374 @default.
• W3177562774 cites W3137399724 @default.
• W3177562774 cites W3139537696 @default.
• W3177562774 cites W3166908185 @default.
• W3177562774 doi "https://doi.org/10.3390/antibiotics10070833" @default.
• W3177562774 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8300715" @default.
• W3177562774 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34356754" @default.
• W3177562774 hasPublicationYear "2021" @default.
• W3177562774 type Work @default.
• W3177562774 sameAs 3177562774 @default.
• W3177562774 citedByCount "4" @default.
• W3177562774 countsByYear W31775627742021 @default.
• W3177562774 countsByYear W31775627742022 @default.
• W3177562774 countsByYear W31775627742023 @default.
• W3177562774 crossrefType "journal-article" @default.
• W3177562774 hasAuthorship W3177562774A5000611736 @default.
• W3177562774 hasAuthorship W3177562774A5005522906 @default.
• W3177562774 hasAuthorship W3177562774A5014959417 @default.
• W3177562774 hasAuthorship W3177562774A5026946798 @default.
• W3177562774 hasAuthorship W3177562774A5029196815 @default.
• W3177562774 hasAuthorship W3177562774A5076790643 @default.
• W3177562774 hasAuthorship W3177562774A5077568724 @default.
• W3177562774 hasAuthorship W3177562774A5090976729 @default.
• W3177562774 hasBestOaLocation W31775627741 @default.
• W3177562774 hasConcept C104317684 @default.
• W3177562774 hasConcept C105702510 @default.
• W3177562774 hasConcept C114851261 @default.
• W3177562774 hasConcept C118687296 @default.
• W3177562774 hasConcept C2776315533 @default.
• W3177562774 hasConcept C2777637488 @default.
• W3177562774 hasConcept C2778022156 @default.
• W3177562774 hasConcept C2778597219 @default.
• W3177562774 hasConcept C2778607973 @default.
• W3177562774 hasConcept C4937899 @default.

• next