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• W3177599374 endingPage "106034" @default.
• W3177599374 startingPage "106034" @default.
• W3177599374 abstract "Primary immunodeficiencies (PIDs) are associated with deleterious mutations of genes that encode proteins involved in actin cytoskeleton reorganisation. This deficiency affects haematopoietic cells. PID results in the defective function of immune cells, such as impaired chemokine-induced motility, receptor signalling, development and maturation. Some of the genes mutated in PIDs are related to small Ras homologous (Rho) guanosine triphosphatase (GTPase), one of the families of the Ras superfamily. Most of these genes act as molecular switches by cycling between active guanosine triphosphate-bound and inactive guanosine diphosphate-bound forms to control multiple cellular functions. They are best studied for their role in promoting cytoskeleton reorganisation, cell adhesion and motility. Currently, only three small Rho GTPases, namely, Rac2, Cdc42 and RhoH, have been identified in PIDs. However, several other Rho small G proteins might also contribute to the deregulation and phenotype observed in PIDs. Their contribution in PIDs may involve their main regulator, Rho guanine nucleotide exchange factors such as DOCK2 and DOCK8, wherein mutations may result in the impairment of small Rho GTPase activation. Thus, this review outlines the potential contribution of several small Rho GTPases to the promotion of PIDs." @default.
• W3177599374 created "2021-07-19" @default.
• W3177599374 creator A5069081871 @default.
• W3177599374 creator A5074187993 @default.
• W3177599374 date "2021-08-01" @default.
• W3177599374 modified "2023-09-27" @default.
• W3177599374 title "Small Rho GTPases and their associated RhoGEFs mutations promote immunological defects in primary immunodeficiencies" @default.
• W3177599374 cites W1485975953 @default.
• W3177599374 cites W1519673405 @default.
• W3177599374 cites W1551667737 @default.
• W3177599374 cites W1560364786 @default.
• W3177599374 cites W1704185171 @default.
• W3177599374 cites W1758664679 @default.
• W3177599374 cites W1910650341 @default.
• W3177599374 cites W1925706823 @default.
• W3177599374 cites W1968826282 @default.
• W3177599374 cites W1971286181 @default.
• W3177599374 cites W1972641293 @default.
• W3177599374 cites W1973286130 @default.
• W3177599374 cites W1975360666 @default.
• W3177599374 cites W1976141600 @default.
• W3177599374 cites W1976233823 @default.
• W3177599374 cites W1980354175 @default.
• W3177599374 cites W1982269054 @default.
• W3177599374 cites W1982323892 @default.
• W3177599374 cites W1983085370 @default.
• W3177599374 cites W1993735775 @default.
• W3177599374 cites W1997537329 @default.
• W3177599374 cites W2001303884 @default.
• W3177599374 cites W2007289852 @default.
• W3177599374 cites W2007660746 @default.
• W3177599374 cites W2007903825 @default.
• W3177599374 cites W2008063123 @default.
• W3177599374 cites W2009542532 @default.
• W3177599374 cites W2010529338 @default.
• W3177599374 cites W2010630254 @default.
• W3177599374 cites W2011960178 @default.
• W3177599374 cites W2022716167 @default.
• W3177599374 cites W2022855448 @default.
• W3177599374 cites W2025896887 @default.
• W3177599374 cites W2031545497 @default.
• W3177599374 cites W2033801205 @default.
• W3177599374 cites W2035325286 @default.
• W3177599374 cites W2035754589 @default.
• W3177599374 cites W2045375145 @default.
• W3177599374 cites W2049897598 @default.
• W3177599374 cites W2053257956 @default.
• W3177599374 cites W2058600007 @default.
• W3177599374 cites W2058742122 @default.
• W3177599374 cites W2061162326 @default.
• W3177599374 cites W2061988258 @default.
• W3177599374 cites W2069544366 @default.
• W3177599374 cites W2069738597 @default.
• W3177599374 cites W2071549331 @default.
• W3177599374 cites W2075238900 @default.
• W3177599374 cites W2084978375 @default.
• W3177599374 cites W2086204346 @default.
• W3177599374 cites W2087172814 @default.
• W3177599374 cites W2091169894 @default.
• W3177599374 cites W2092919466 @default.
• W3177599374 cites W2093832003 @default.
• W3177599374 cites W2094377686 @default.
• W3177599374 cites W2094577052 @default.
• W3177599374 cites W2095562167 @default.
• W3177599374 cites W2099957891 @default.
• W3177599374 cites W2101129972 @default.
• W3177599374 cites W2102312968 @default.
• W3177599374 cites W2102523981 @default.
• W3177599374 cites W2102821093 @default.
• W3177599374 cites W2103045846 @default.
• W3177599374 cites W2104485568 @default.
• W3177599374 cites W2106600469 @default.
• W3177599374 cites W2106848617 @default.
• W3177599374 cites W2112572394 @default.
• W3177599374 cites W2120070306 @default.
• W3177599374 cites W2126915765 @default.
• W3177599374 cites W2127984915 @default.
• W3177599374 cites W2135743634 @default.
• W3177599374 cites W2137850515 @default.
• W3177599374 cites W2142127956 @default.
• W3177599374 cites W2146783761 @default.
• W3177599374 cites W2148324690 @default.
• W3177599374 cites W2153070402 @default.
• W3177599374 cites W2154076996 @default.
• W3177599374 cites W2157943033 @default.
• W3177599374 cites W2159683137 @default.
• W3177599374 cites W2160600730 @default.
• W3177599374 cites W2165083476 @default.
• W3177599374 cites W2165464440 @default.
• W3177599374 cites W2167808722 @default.
• W3177599374 cites W2168091755 @default.
• W3177599374 cites W2429042322 @default.
• W3177599374 cites W2494853255 @default.
• W3177599374 cites W2511442010 @default.
• W3177599374 cites W2534647638 @default.
• W3177599374 cites W2555716674 @default.
• W3177599374 cites W2604456522 @default.
• W3177599374 cites W2624092568 @default.

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