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- W3177661721 abstract "Background: Postsurgical recurrence within 2 years occurs in 30-50% of Hepatocellular carcinoma (HCC) patients, being the major cause of mortality. We have reported that high expression of Sec62 was found in surgical recurrence patients of HCC from a retrospective study. However, the role and mechanism of Sec62 in HCC recurrence remains poorly understand. Here we distinguish the the function of Sec62 in early HCC recurrence.Methods: A luciferase-labeled orthotopic model of HCC with Sec62 overexpressed or downregulated, seperately was used to validate the potential of Sec62 in early HCC recurrence in vivo. The microarray analysis comparing Sec62low or Sec62high and their control counterparts was used to explore targets in Sec62 induced recurrence. The role of Sec62 was further proved in 60 HCC patients undergoing surgical resection from a prospective study.Findings: We found that Sec62 overexpression promoted postsurgical recurrence in vivo and the migration and invasion of HCC cells in vitro. Mechanically, integrin α/CAV1 signaling was identified as a target of Sec62 for cells movement. Up-regulation of integrin α and CAV1 rescued the decreased cell migration and invasion, which were induced by Sec62 knockdown. Furthermore, high expression of Sec62 was correlated with surgical recurrence in clinical HCC samples and positively correlated with Integrin α/CAV1 signaling. Multivariate analysis revealed that Sec62 was an independent prognostic indicator for cumulative recurrence in this cohort of HCC patients post-surgical.Interpretation: Overexpression of Sec62 was implicated in recurrence of HCC after surgical and Sec62 overexpression may be a potential molecular therapeutic targets for HCC. Funding: This work was supported by National Nature Science Foundation of China (grant number: 81473484) and Nature Science Foundation of Shanghai (grant number: 14ZR1408400).Declaration of Interest: The authors declare that they have no conflict of interest.Ethical Approval: The animal protocols were performed in agreement with SIBS Guide for the Care and Use of Laboratory Animals and were approved by Animal Ethics Committee of Zhongshan Hospital, Fudan University." @default.
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- W3177661721 date "2019-01-01" @default.
- W3177661721 modified "2023-10-14" @default.
- W3177661721 title "Sec62 Promotes Hepatocellular Carcinoma Metastasis Through Integrinα-CAV1 Signaling and Predicts Surgical Recurrence of Patients" @default.
- W3177661721 doi "https://doi.org/10.2139/ssrn.3373844" @default.
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