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- W3177685041 abstract "Guanidinoglycosides are a class of non-cytotoxic molecular transporters capable of delivering high molecular weight bioactive cargos into cells at low nanomolar concentrations. Efficient bioconjugation with guanidinoglycosides has been previously demonstrated by utilizing a guanidinoneomycin decorated with a reactive but also unstable N-hydroxysuccinimmide ester-containing linker. Herein we report the synthesis, chemistry, and application of a new, stable guanidinoneomycin derivative armed with a highly specific maleimide moiety which allows for thiol-maleimide click chemistry, a highly popular bioconjugation strategy, widening the field of application of these intriguing and useful delivery vehicles." @default.
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- W3177685041 date "2021-01-01" @default.
- W3177685041 modified "2023-10-17" @default.
- W3177685041 title "Guanidinoneomycin-maleimide molecular transporter: synthesis, chemistry and cellular uptake" @default.
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- W3177685041 doi "https://doi.org/10.1039/d1ob01101d" @default.
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